PMID- 22227468
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20120403
IS  - 1769-6658 (Electronic)
IS  - 1278-3218 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Apr
TI  - [Involved-node radiotherapy combined with deep-inspiration breath-hold technique 
      in patients with Hodgkin lymphoma].
PG  - 85-90
LID - 10.1016/j.canrad.2011.07.245 [doi]
AB  - PURPOSE: To assess the clinical outcome of the involved-node radiotherapy (INRT) 
      concept with the use of deep-inspiration breath-hold (DIBH) technique in patients 
      with localized supra-diaphragmatic Hodgkin lymphoma. PATIENTS AND METHODS: All 
      were patients with stage I-II Hodgkin lymphoma and they were treated with 
      chemotherapy prior to irradiation. Radiation treatments were delivered using the 
      involved-node radiotherapy concept according to the European Organization for 
      Research and Treatment of Cancer Guidelines and a spirometer dedicated to DIBH 
      radiotherapy was used for every patient. RESULTS: Twenty-seven patients with 
      Hodgkin lymphoma (26 patients with primary Hodgkin lymphoma, one with refractory 
      disease), treated from November 2004 to October 2010, were retrospectively 
      analysed. The median age was 27 years (range 16 to 54). Seventeen (63%) patients 
      had stage I-IIA and 10 (37%) had stage I-IIB disease. All patients received two 
      to six cycles of adriamycin, bleomycin, vinblastine and dacarbazine. The median 
      radiation dose to patients was 30,6 Gy (range: 19,8-40). Protection of various 
      organs at risk was satisfactory. Median follow-up, 3-year progression-free and 
      3-year overall survival were 38 months (range: 7-70), 96% (95%CI: 79-99%) and 95% 
      (95%CI: 75-99%), respectively. Recurrence occurred in one patient (mediastinal 
      in-field relapse). There was one grade 3 acute toxicity (transient pneumonitis). 
      CONCLUSIONS: Our results suggest that patients with localized Hodgkin lymphoma 
      can be safely and efficiently treated using deep-inspiration breath technique and 
      the involved-node radiotherapy concept. Longer follow-up is needed to assess late 
      toxicity, especially for the heart and the coronary arteries.
CI  - Copyright (c) 2011 Societe francaise de radiotherapie oncologique (SFRO). Published 
      by Elsevier SAS. All rights reserved.
FAU - Paumier, A
AU  - Paumier A
AD  - Departement de radiotherapie, institut Gustave-Roussy, Villejuif, France. 
      amaury.paumier@ico.unicancer.fr
FAU - Bakkour, M
AU  - Bakkour M
FAU - Ghalibafian, M
AU  - Ghalibafian M
FAU - Beaudre, A
AU  - Beaudre A
FAU - Blanchard, P
AU  - Blanchard P
FAU - Martinetti, F
AU  - Martinetti F
FAU - Girinsky, T
AU  - Girinsky T
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Optimisation de la radiotherapie involved-node grace a l'inspiration profonde 
      bloquee dans la maladie de Hodgkin.
DEP - 20120109
PL  - France
TA  - Cancer Radiother
JT  - Cancer radiotherapie : journal de la Societe francaise de radiotherapie 
      oncologique
JID - 9711272
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Diaphragm
MH  - Female
MH  - Hodgkin Disease/*radiotherapy
MH  - Humans
MH  - Inhalation
MH  - Male
MH  - Middle Aged
MH  - Radiotherapy/methods
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2012/01/10 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/01/10 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/06/28 00:00 [revised]
PHST- 2011/07/06 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - S1278-3218(11)00449-5 [pii]
AID - 10.1016/j.canrad.2011.07.245 [doi]
PST - ppublish
SO  - Cancer Radiother. 2012 Apr;16(2):85-90. doi: 10.1016/j.canrad.2011.07.245. Epub 
      2012 Jan 9.