PMID- 22227511
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20120501
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 343
IP  - 5
DP  - 2012 May
TI  - A fatal case of kaposi sarcoma due to immune reconstitution inflammatory 
      syndrome.
PG  - 421-5
LID - 10.1097/MAJ.0b013e31823eff35 [doi]
AB  - The prevalence of AIDS-related Kaposi sarcoma (KS) has markedly declined in the 
      era of highly active antiretroviral therapy (HAART) although it remains one of 
      the most common AIDS-defining malignancies. Although immune reconstitution 
      inflammatory syndrome (IRIS)-related KS (IRIS-KS) represents only a fraction of 
      the IRIS cases, it can be a life-threatening situation. This report describes a 
      fatal case of IRIS-KS. A 32-year-old man with HIV/AIDS was initiated on HAART and 
      experienced rapid immunological and virological response to therapy. He 
      subsequently experienced progressively severe dyspnea and papulonodular skin 
      lesions and was admitted to the hospital with hypoxic respiratory failure. 
      Bronchoscopy revealed numerous friable endobronchial lesions. Histopathology of a 
      skin lesion was consistent with KS. The relatively rapid progression of disease 
      in the setting of improvement in immune function after initiating HAART suggested 
      IRIS-KS. This report reviews previously published cases of IRIS-KS and describes 
      risk factors, immunopathogenesis and treatment options.
FAU - Stover, Kayla R
AU  - Stover KR
AD  - Department of Pharmacy Practice, University of Mississippi School of Pharmacy, 
      University of Mississippi Medical Center, Jackson, 39216, USA. kstover@umc.edu
FAU - Molitorisz, Szilvia
AU  - Molitorisz S
FAU - Swiatlo, Edwin
AU  - Swiatlo E
FAU - Muzny, Christina A
AU  - Muzny CA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/complications/drug therapy
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Bronchial Diseases/*etiology
MH  - Fatal Outcome
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications
MH  - Male
MH  - Sarcoma, Kaposi/*etiology
MH  - Skin Neoplasms/*etiology
EDAT- 2012/01/10 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - S0002-9629(15)30978-2 [pii]
AID - 10.1097/MAJ.0b013e31823eff35 [doi]
PST - ppublish
SO  - Am J Med Sci. 2012 May;343(5):421-5. doi: 10.1097/MAJ.0b013e31823eff35.