PMID- 22227998
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20211021
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Mar
TI  - A decrease in the percentage of circulating mDC precursors in patients with 
      coronary heart disease: a relation to the severity and extent of coronary artery 
      lesions?
PG  - 135-42
LID - 10.1007/s00380-011-0218-1 [doi]
AB  - Inflammation plays a pivotal role in coronary heart disease. Dendritic cells 
      (DCs) are principal players in inflammation and atherosclerosis. Although the 
      percentage of circulating DC precursors in coronary heart disease have been 
      investigated, circulating myeloid DC (mDC) and plasmacytoid DC (pDC) precursors 
      have not been extensively studied, particularly in relation to the severity of 
      coronary artery lesions in patients with coronary heart disease. In this study, 
      we recruited controls (n = 29), patients with stable angina pectoris (SAP, n = 
      30), patients with unstable angina pectoris (UAP, n = 56), and patients with 
      acute myocardial infarction (AMI, n = 50). The severity and extent of coronary 
      artery lesions was evaluated by Gensini score, following coronary angiograms. The 
      percentage of circulating mDC and pDC precursors was determined by 
      fluorescence-activated cell sorting (FACS). Plasma levels of MCP-1 and MMP-9, 
      which correlate with atherosclerosis and DC migration, were also measured. The 
      percentage of circulating mDC precursors was reduced in patients with AMI and UAP 
      compared with control and SAP patients, respectively (p < 0.01 for AMI vs. SAP 
      and Control, p < 0.05 for UAP vs. SAP and Control). The percentage of circulating 
      pDC precursors was not significant changed. The levels of plasma MMP-9 and MCP-1 
      and Genisi score were all increased in patients with AMI and UAP, compared to 
      control and SAP patients, respectively (p < 0.01 for AMI vs. SAP and control, p < 
      0.05 for UAP vs. SAP and control). Overall, the percentage of circulating mDC 
      precursors was negatively correlated with MCP-1 (p < 0.001), MMP-9 (p < 0.001) 
      and Genisi scores (p < 0.001). Genisi scores were positively correlated with the 
      levels of MCP-1 (p < 0.001) and MMP-9 (p < 0.001). Our study suggested that the 
      percentage of circulating mDC precursors is negatively correlated with the 
      severity and extent of coronary artery lesions in patients with coronary heart 
      disease.
FAU - Wen, Jin
AU  - Wen J
AD  - Cardiovascular Department, Zhujiang Hospital, Southern Medical University, Haizhu 
      Area, Guangzhou, Guangdong, China.
FAU - Wen, Yan
AU  - Wen Y
FAU - Zhiliang, Li
AU  - Zhiliang L
FAU - Lingling, Chen
AU  - Lingling C
FAU - Longxing, Cao
AU  - Longxing C
FAU - Ming, Wang
AU  - Ming W
FAU - Qiang, Fu
AU  - Qiang F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120107
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina, Stable/diagnosis/immunology/pathology
MH  - Angina, Unstable/diagnosis/immunology/pathology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cell Count
MH  - Cell Separation/methods
MH  - Chemokine CCL2/blood
MH  - Chi-Square Distribution
MH  - Coronary Angiography
MH  - Coronary Artery Disease/blood/*diagnosis/immunology/pathology
MH  - Coronary Vessels/diagnostic imaging/*pathology
MH  - Dendritic Cells/*immunology
MH  - Disease Progression
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/immunology/pathology
MH  - *Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
EDAT- 2012/01/10 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/01/10 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2011/12/08 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 10.1007/s00380-011-0218-1 [doi]
PST - ppublish
SO  - Heart Vessels. 2013 Mar;28(2):135-42. doi: 10.1007/s00380-011-0218-1. Epub 2012 
      Jan 7.