PMID- 22228416
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20120208
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 93
IP  - 4
DP  - 2012 Feb 27
TI  - Allosensitization rate of male patients awaiting first kidney grafts after 
      leuko-depleted blood transfusion.
PG  - 418-22
LID - 10.1097/TP.0b013e3182419864 [doi]
AB  - BACKGROUND: Blood transfusions are generally avoided for potential renal 
      transplant recipients due to risk of human leukocyte antigen (HLA) 
      allosensitization. Despite the near universal use of erythropoiesis-stimulating 
      agents, there are still occasions when patients require blood transfusions for 
      reasons such as resistance to erythropoiesis-stimulating agents or cardiovascular 
      instability. The risk of allosensitization in renal patients is believed to be 
      lower with leuko-depleted blood. We sought to quantify the risk of blood 
      transfusion per se in male renal patients on the transplant waiting list for 
      their first kidney graft, using sensitive solid phase antibody detection. METHOD: 
      Cross-sectional survey looking at the prevalence of HLA antibody detected using 
      single antigen Luminex beads in male patients awaiting first renal 
      transplantation. RESULTS: One hundred sixteen male patients awaiting their first 
      kidney transplant were identified on our waiting list. Seven of the 42 patients 
      (16.7%) who received at least one unit of leuko-depleted blood developed HLA 
      antibody (HLAab). Of the remaining 74 patients without a history of transfusion, 
      3 (4.1%) were found to have HLAab. All the antibodies identified were directed 
      against class I antigens. A history of blood transfusion gave a relative risk of 
      4.1 of developing HLAab (P=0.02). CONCLUSION: Male patients awaiting their first 
      organ transplant had a fourfold increased risk of developing HLA antibody if they 
      had been previously transfused when compared with those who did not have a 
      history of a transfusion. Transfusion even in the postleukodepletion era 
      continues to pose a significant risk of sensitization.
FAU - Balasubramaniam, Gowrie S
AU  - Balasubramaniam GS
AD  - Department of Nephrology and Transplantation, MRC Centre for Transplantation, 
      Guy's and St. Thomas' Hospital, Great Maze Pond, Southwark, London, United 
      Kingdom. gowrie@doctors.net.uk
FAU - Morris, Matthew
AU  - Morris M
FAU - Gupta, Arun
AU  - Gupta A
FAU - Mesa, Irene Rebello
AU  - Mesa IR
FAU - Thuraisingham, Raj
AU  - Thuraisingham R
FAU - Ashman, Neil
AU  - Ashman N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Antibodies/*blood
MH  - *Blood Transfusion
MH  - Cross-Sectional Studies
MH  - Graft Survival/immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Immunization/*statistics & numerical data
MH  - *Kidney Transplantation/immunology
MH  - *Leukocyte Reduction Procedures
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Survival Rate
MH  - Waiting Lists
EDAT- 2012/01/10 06:00
MHDA- 2012/04/21 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - 10.1097/TP.0b013e3182419864 [doi]
PST - ppublish
SO  - Transplantation. 2012 Feb 27;93(4):418-22. doi: 10.1097/TP.0b013e3182419864.