PMID- 22228969
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20220330
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Jan 7
TI  - Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen 
      test.
PG  - 44-8
LID - 10.3748/wjg.v18.i1.44 [doi]
AB  - AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool 
      antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study 
      assessed 28 patients [16 men and 12 women; mean age (63.1 +/- 5.9) years; range, 
      25-84 years] who underwent stool antigen test and urea breath test (UBT) before 
      and after PPI administration. RESULTS: Using the UBT as the standard, the 
      sensitivity, specificity and agreement of the stool antigen test in all 28 
      patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, 
      and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values 
      were 23.98% +/- 5.33% before and 16.19% +/- 4.75% after PPI treatment and, in 15 
      patients treated for >/= 4 wk, were significantly lower after than before 4 wk of 
      PPI treatment (12.58% +/- 4.49% vs 24.53% +/- 8.53%, P = 0.048). The mean optical 
      density (A(450/630)) ratios on the stool antigen test were 1.16 +/- 0.20 before and 
      1.17 +/- 0.24 after PPI treatment (P = 0.989), and were 1.02 +/- 0.26 and 0.69 +/- 
      0.28, respectively, in the group treated for > 4 wk (P = 0.099). CONCLUSION: The 
      stool antigen test was equally sensitive to the UBT, making it a useful and 
      reliable diagnostic method, even during PPI administration.
FAU - Kodama, Masaaki
AU  - Kodama M
AD  - Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu city, 
      Oita 879-5593, Japan. kodm@oita-u.ac.jp
FAU - Murakami, Kazunari
AU  - Murakami K
FAU - Okimoto, Tadayoshi
AU  - Okimoto T
FAU - Fukuda, Yoshihiro
AU  - Fukuda Y
FAU - Shimoyama, Tadashi
AU  - Shimoyama T
FAU - Okuda, Masumi
AU  - Okuda M
FAU - Kato, Chieko
AU  - Kato C
FAU - Kobayashi, Intetsu
AU  - Kobayashi I
FAU - Fujioka, Toshio
AU  - Fujioka T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Proton Pump Inhibitors)
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Antigens, Bacterial
MH  - Breath Tests/methods
MH  - Feces/*microbiology
MH  - Female
MH  - Helicobacter Infections/*diagnosis/*drug therapy
MH  - Helicobacter pylori/*drug effects/immunology
MH  - Humans
MH  - Immunoenzyme Techniques/methods/standards
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Sensitivity and Specificity
MH  - Urea
PMC - PMC3251804
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - Proton pump inhibitor
OT  - Stool antigen test
OT  - Urea breath test
EDAT- 2012/01/10 06:00
MHDA- 2012/03/07 06:00
PMCR- 2012/01/07
CRDT- 2012/01/10 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/07/06 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
PHST- 2012/01/07 00:00 [pmc-release]
AID - 10.3748/wjg.v18.i1.44 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Jan 7;18(1):44-8. doi: 10.3748/wjg.v18.i1.44.