PMID- 22230156 OWN - NLM STAT- MEDLINE DCOM- 20120516 LR - 20161125 IS - 1876-7605 (Electronic) IS - 1936-8798 (Linking) VI - 5 IP - 1 DP - 2012 Jan TI - Percutaneous edge-to-edge mitral valve repair in high-surgical-risk patients: do we hit the target? PG - 105-11 LID - 10.1016/j.jcin.2011.09.013 [doi] AB - OBJECTIVES: This study sought to assess the feasibility and safety of percutaneous edge-to-edge mitral valve (MV) repair in patients with an unacceptably high operative risk. BACKGROUND: MV repair for mitral regurgitation (MR) can be accomplished by use of a clip that approximates the free edges of the mitral leaflets. METHODS: All patients were declined for surgery because of a high logistic EuroSCORE (>20%) or the presence of other specific surgical risk factors. Transthoracic echocardiography was performed before and 6 months after the procedure. Differences in New York Heart Association (NYHA) functional class, quality of life (QoL) using the Minnesota questionnaire, and 6-min walk test (6-MWT) distances were reported. RESULTS: Fifty-five procedures were performed in 52 patients (69.2% male, age 73.2 +/- 10.1 years, logistic EuroSCORE 27.1 +/- 17.0%). In 3 patients, partial clip detachment occurred; a second clip was placed successfully. One patient experienced cardiac tamponade. Two patients developed inguinal bleeding, of whom 1 needed surgery. Six patients (11.5%) died during 6-month follow-up (5 patients as a result of progressive heart failure and 1 noncardiac death). The MR grade before repair was >/=3 in 100%; after 6 months, a reduction in MR grade to