PMID- 22230228 OWN - NLM STAT- MEDLINE DCOM- 20120720 LR - 20211021 IS - 1873-3514 (Electronic) IS - 0028-3932 (Print) IS - 0028-3932 (Linking) VI - 50 IP - 5 DP - 2012 Apr TI - Medial prefrontal functional connectivity--relation to memory self-appraisal accuracy in older adults with and without memory disorders. PG - 603-11 LID - 10.1016/j.neuropsychologia.2011.12.014 [doi] AB - It is tentatively estimated that 25% of people with early Alzheimer's disease (AD) show impaired awareness of disease-related changes in their own cognition. Research examining both normative self-awareness and altered awareness resulting from brain disease or injury points to the central role of the medial prefrontal cortex (MPFC) in generating accurate self-appraisals. The current project builds on this work - examining changes in MPFC functional connectivity that correspond to impaired self-appraisal accuracy early in the AD time course. Our behavioral focus was self-appraisal accuracy for everyday memory function, and this was measured using the Memory Function Scale of the Memory Awareness Rating Scale - an instrument psychometrically validated for this purpose. Using regression analysis of data from people with healthy memory (n=12) and people with impaired memory due to amnestic mild cognitive impairment or early AD (n=12), we tested the hypothesis that altered MPFC functional connectivity - particularly with other cortical midline structures and dorsolateral prefrontal cortex - explains variation in memory self-appraisal accuracy. We spatially constrained (i.e., explicitly masked) our regression analyses to those regions that work in conjunction with the MPFC to evoke self-appraisals in a normative group. This empirically derived explicit mask was generated from the result of a psychophysiological interaction analysis of fMRI self-appraisal task data in a separate, large group of cognitively healthy individuals. Results of our primary analysis (i.e., the regression of memory self-appraisal accuracy on MPFC functional connectivity) were generally consistent with our hypothesis: people who were less accurate in making memory self-appraisals showed attenuated functional connectivity between the MPFC seed region and proximal areas within the MPFC (including subgenual anterior cingulate cortex), bilateral dorsolateral prefrontal cortex, bilateral caudate, and left posterior hippocampus. Contrary to our expectations, MPFC functional connectivity with the posterior cingulate was not significantly related to accuracy of memory self-appraisals. Results reported here corroborate findings of variable memory self-appraisal accuracy during the earliest emergence of AD symptoms and reveal alterations in MPFC functional connectivity that correspond to impaired memory self-appraisal. CI - Copyright (c) 2012 Elsevier Ltd. All rights reserved. FAU - Ries, Michele L AU - Ries ML AD - Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. mlr@medicine.wisc.edu FAU - McLaren, Donald G AU - McLaren DG FAU - Bendlin, Barbara B AU - Bendlin BB FAU - Guofanxu AU - Guofanxu FAU - Rowley, Howard A AU - Rowley HA FAU - Birn, Rasmus AU - Birn R FAU - Kastman, Erik K AU - Kastman EK FAU - Sager, Mark A AU - Sager MA FAU - Asthana, Sanjay AU - Asthana S FAU - Johnson, Sterling C AU - Johnson SC LA - eng GR - UL1 RR025011-04/RR/NCRR NIH HHS/United States GR - R01 AG021155-08/AG/NIA NIH HHS/United States GR - P50 AG033514-04/AG/NIA NIH HHS/United States GR - 1UL1RR025011/RR/NCRR NIH HHS/United States GR - P50 AG033514-03/AG/NIA NIH HHS/United States GR - R01AG21155/AG/NIA NIH HHS/United States GR - P50 AG033514/AG/NIA NIH HHS/United States GR - P50AG033514/AG/NIA NIH HHS/United States GR - P30 HD003352/HD/NICHD NIH HHS/United States GR - R01 AG027161/AG/NIA NIH HHS/United States GR - R01AG027161/AG/NIA NIH HHS/United States GR - UL1 RR025011/RR/NCRR NIH HHS/United States GR - R01 AG021155/AG/NIA NIH HHS/United States GR - R01 AG027161-04/AG/NIA NIH HHS/United States GR - R01 AG021155-09/AG/NIA NIH HHS/United States GR - R01 AG027161-05/AG/NIA NIH HHS/United States GR - UL1 RR025011-05/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20120102 PL - England TA - Neuropsychologia JT - Neuropsychologia JID - 0020713 RN - S88TT14065 (Oxygen) SB - IM MH - Aged MH - Aged, 80 and over MH - Awareness/*physiology MH - Brain Mapping MH - *Diagnostic Self Evaluation MH - Female MH - Humans MH - Image Processing, Computer-Assisted MH - Magnetic Resonance Imaging MH - Male MH - Memory Disorders/*diagnosis/*psychology MH - Middle Aged MH - Neuropsychological Tests MH - Oxygen/blood MH - Perceptual Masking MH - Prefrontal Cortex/blood supply/*physiopathology MH - Psychometrics MH - Regression Analysis PMC - PMC3537182 MID - NIHMS352069 EDAT- 2012/01/11 06:00 MHDA- 2012/07/21 06:00 PMCR- 2013/04/01 CRDT- 2012/01/11 06:00 PHST- 2011/08/08 00:00 [received] PHST- 2011/12/09 00:00 [revised] PHST- 2011/12/22 00:00 [accepted] PHST- 2012/01/11 06:00 [entrez] PHST- 2012/01/11 06:00 [pubmed] PHST- 2012/07/21 06:00 [medline] PHST- 2013/04/01 00:00 [pmc-release] AID - S0028-3932(11)00559-8 [pii] AID - 10.1016/j.neuropsychologia.2011.12.014 [doi] PST - ppublish SO - Neuropsychologia. 2012 Apr;50(5):603-11. doi: 10.1016/j.neuropsychologia.2011.12.014. Epub 2012 Jan 2.