PMID- 22231032
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20171116
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 27
IP  - 6
DP  - 2012 Jun
TI  - Do albuminuria and hs-CRP add to the International Diabetes Federation definition 
      of the metabolic syndrome in predicting outcome?
PG  - 2275-83
LID - 10.1093/ndt/gfr634 [doi]
AB  - BACKGROUND: To investigate the added value of elevated urinary albumin excretion 
      (UAE) and high high-sensitive C-reactive protein (hs-CRP) in predicting new-onset 
      type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD) and chronic kidney 
      disease (CKD) in addition to the present metabolic syndrome (MetS) defining 
      criteria. METHODS: The PREVEND Study is a prospective population-based cohort 
      study in the Netherlands, including 8592 participants. The MetS was defined 
      according to the 2004 International Diabetes Federation criteria, elevated UAE as 
      albuminuria >/= 30 mg/24 h and high hs-CRP as >/= 3 mg/L. RESULTS: At follow-up, 
      subjects without MetS when compared to subjects with MetS had a lower incidence 
      of T2DM, CVD as well as CKD (2.5 versus 15.5; 4.1 versus 10.3 and 5.8 versus 
      11.2%, all P < 0.001). In subjects with MetS, the incidence of all three outcomes 
      was higher among subjects with elevated albuminuria versus subjects with 
      normoalbuminuria (all P < 0.01). The incidence of all outcomes was also higher 
      among subjects with high hs-CRP versus subjects without elevated hs-CRP but only 
      significant for CKD (P = 0.002). Multivariate analysis including elevated UAE, 
      hs-CRP and the variables defining the MetS showed that elevated albuminuria was 
      independently associated with the risk for new-onset T2DM, CVD and CKD, whereas 
      high hs-CRP was only independently associated with new-onset CVD and CKD. 
      CONCLUSION: Our data show that elevated UAE has added value to the present MetS 
      defining variables in predicting new-onset T2DM, CVD and CKD, whereas hs-CRP adds 
      to predicting new-onset CVD and CKD, but not T2DM.
FAU - van der Velde, Marije
AU  - van der Velde M
AD  - Division of Nephrology, Department of Medicine, University Medical Center 
      Groningen, University Hospital Groningen, Groningen, The Netherlands.
FAU - Bello, Aminu K
AU  - Bello AK
FAU - Brantsma, Auke H
AU  - Brantsma AH
FAU - El Nahas, Meguid
AU  - El Nahas M
FAU - Bakker, Stephan J L
AU  - Bakker SJ
FAU - de Jong, Paul E
AU  - de Jong PE
FAU - Gansevoort, Ronald T
AU  - Gansevoort RT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120109
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Albuminuria/*diagnosis/epidemiology/etiology
MH  - Blood Pressure
MH  - C-Reactive Protein/*metabolism
MH  - Cardiovascular Diseases/*diagnosis/epidemiology/etiology
MH  - Creatinine/blood
MH  - Diabetes Mellitus, Type 2/*diagnosis/epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Incidence
MH  - International Agencies
MH  - Kidney Failure, Chronic/*diagnosis/epidemiology/etiology
MH  - Male
MH  - Metabolic Syndrome/*complications/*metabolism
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2012/01/11 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/01/11 06:00
PHST- 2012/01/11 06:00 [entrez]
PHST- 2012/01/11 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - gfr634 [pii]
AID - 10.1093/ndt/gfr634 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2012 Jun;27(6):2275-83. doi: 10.1093/ndt/gfr634. Epub 
      2012 Jan 9.