PMID- 22231554
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20211021
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 9
IP  - 3
DP  - 2012 May
TI  - Salmeterol attenuates the inflammatory response in asthma and decreases the 
      pro-inflammatory cytokine secretion of dendritic cells.
PG  - 267-75
LID - 10.1038/cmi.2011.56 [doi]
AB  - Salmeterol is a long-acting beta2-agonist that activates adenylate cyclase, causing 
      long-lasting bronchodilation and has been used for many years to control asthma. 
      However, little information is available about the immunoregulatory effects of 
      salmeterol. We found that salmeterol decreases the production of pro-inflammatory 
      cytokines in a model of allergen-challenged mice that expressed tumor-necrosis 
      factor-alpha, interleukin-1 and interleukin-6. Dendritic cells (DCs) are 
      antigen-presenting cells and act as sentinels in the airway. We found that 
      salmeterol (10(-5) mol/l) reduced the inflammation caused by lipopolysaccharide 
      (0.1 microg/ml) in activated murine bone marrow-derived DCs. Moreover, western blots 
      demonstrated that this protective effect was mediated partially by inhibiting 
      signaling through the nuclear factor-kappa B (NF-kappaB), mitogen-activated protein 
      kinase (MAPK) pathways and dramatically decreased levels of p-ERK. We suggest 
      that salmeterol regulates the inflammation of allergen-induced asthma by 
      modulating DCs. In conclusion, we provide evidence that DCs are the target immune 
      cells responsible for the action of salmeterol against asthma.
FAU - Hu, Zhenli
AU  - Hu Z
AD  - Department of Respiratory Medicine, Changhai Hospital, the Second Military 
      Medical University, Shanghai 200433, China.
FAU - Chen, Ruohua
AU  - Chen R
FAU - Cai, Zhijian
AU  - Cai Z
FAU - Yu, Lei
AU  - Yu L
FAU - Fei, Yang
AU  - Fei Y
FAU - Weng, Lixia
AU  - Weng L
FAU - Wang, Jinghan
AU  - Wang J
FAU - Ge, Xiahui
AU  - Ge X
FAU - Zhu, Tianyi
AU  - Zhu T
FAU - Wang, Jianli
AU  - Wang J
FAU - Bai, Chong
AU  - Bai C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120109
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Adrenergic beta-2 Receptor Agonists)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 6EW8Q962A5 (Salmeterol Xinafoate)
RN  - 9006-59-1 (Ovalbumin)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Adrenergic beta-2 Receptor Agonists/*administration & dosage
MH  - Albuterol/administration & dosage/*analogs & derivatives
MH  - Animals
MH  - Asthma/*drug therapy/immunology
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*drug effects/immunology
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunization
MH  - Inflammation Mediators/metabolism
MH  - Lipopolysaccharides/administration & dosage
MH  - MAP Kinase Signaling System/drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/metabolism
MH  - Ovalbumin/administration & dosage
MH  - Salmeterol Xinafoate
PMC - PMC4012851
EDAT- 2012/01/11 06:00
MHDA- 2012/09/07 06:00
PMCR- 2012/05/01
CRDT- 2012/01/11 06:00
PHST- 2012/01/11 06:00 [entrez]
PHST- 2012/01/11 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - cmi201156 [pii]
AID - 10.1038/cmi.2011.56 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2012 May;9(3):267-75. doi: 10.1038/cmi.2011.56. Epub 2012 Jan 
      9.