PMID- 22234992
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20161125
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 80
IP  - 1
DP  - 2012 Jul 1
TI  - Transcatheter closure of atrial septal defect in a geriatric population.
PG  - 84-90
LID - 10.1002/ccd.23457 [doi]
AB  - OBJECTIVES: To evaluate the efficacy and safety of transcatheter closure of 
      atrial septal defects (ASD) in patients over 70 years of age. BACKGROUND: 
      Transcatheter closure of ASD is an established procedure in children and young 
      adults, but the benefits of this procedure in geriatric patients are still 
      unclear. METHODS: Between 2005 and 2010, 430 patients with ASD underwent 
      transcatheter closure in our hospital. Among those patients, 30 consecutive 
      patients older than 70 years of age were prospectively evaluated. RESULTS: Mean 
      age at procedure was 75.8 +/- 3.8 years (range: 70-85 years). Mean Qp/Qs was 2.4 +/- 
      0.7 and mean ASD diameter was 20.3 +/- 6.4 mm. Nine patients (30%) had a history of 
      hospitalization due to heart failure. ASD closure was successfully performed in 
      28 patients (93%) without significant complications. During the follow-up period 
      (mean period of 19.1 +/- 11.3 months), New York Heart Association (NYHA) functional 
      class was significantly improved in 20 patients (74%). Significant improvements 
      of plasma BNP level, resting heart rate, and systolic pulmonary artery pressure 
      were also observed. Improvement of tricuspid regurgitation was observed in 11 of 
      17 patients with moderate or severe regurgitation during the follow-up period. 
      Conversely, worsening of mitral regurgitation was observed in 10 of the 27 
      patients. CONCLUSION: Transcatheter closure of ASD in geriatric patients can be 
      performed safely. This procedure contributes to significant improvement of 
      symptoms and positive cardiac remodeling. Long-term follow-up is mandatory, 
      especially for patients with mitral regurgitation.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Nakagawa, Koji
AU  - Nakagawa K
AD  - Department of Cardiovascular Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Akagi, Teiji
AU  - Akagi T
FAU - Taniguchi, Manabu
AU  - Taniguchi M
FAU - Kijima, Yasufumi
AU  - Kijima Y
FAU - Goto, Keiji
AU  - Goto K
FAU - Kusano, Kengo F
AU  - Kusano KF
FAU - Itoh, Hiroshi
AU  - Itoh H
FAU - Sano, Shunji
AU  - Sano S
LA  - eng
PT  - Journal Article
DEP - 20120110
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Catheter Cardiovasc Interv. 2012 Jul 1;80(1):91-2. PMID: 22736588
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - *Cardiac Catheterization/adverse effects
MH  - Female
MH  - Heart Septal Defects, Atrial/blood/complications/diagnostic 
      imaging/physiopathology/*therapy
MH  - Hemodynamics
MH  - Humans
MH  - Japan
MH  - Linear Models
MH  - Male
MH  - Mitral Valve Insufficiency/etiology/therapy
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tricuspid Valve Insufficiency/etiology/therapy
MH  - Ultrasonography
MH  - Ventricular Remodeling
EDAT- 2012/01/12 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/01/12 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/10/29 00:00 [accepted]
PHST- 2012/01/12 06:00 [entrez]
PHST- 2012/01/12 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - 10.1002/ccd.23457 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2012 Jul 1;80(1):84-90. doi: 10.1002/ccd.23457. Epub 
      2012 Jan 10.