PMID- 22235107
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20151119
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 36
IP  - 1
DP  - 2012 Jan
TI  - Evaluation of the effects of a preoperative 2-hour fast with maltodextrine and 
      glutamine on insulin resistance, acute-phase response, nitrogen balance, and 
      serum glutathione after laparoscopic cholecystectomy: a controlled randomized 
      trial.
PG  - 43-52
LID - 10.1177/0148607111422719 [doi]
AB  - BACKGROUND: Prolonged preoperative fasting increases insulin resistance (IR). The 
      authors investigated whether an abbreviated preoperative fast with glutamine 
      (GLN) plus a carbohydrate (CHO)-based beverage would improve the organic response 
      after surgery. METHODS: Forty-eight female patients (19-62 years) were randomized 
      to either standard fasting (control group) or to fasting with 1 of 3 different 
      beverages before video-cholecystectomy. Beverages were consumed 8 hours (400 mL; 
      placebo group: water; GLN group: water with 50 g maltodextrine plus 40 g GLN; and 
      CHO group: water with 50 g maltodextrine) and 2 hours (200 mL; placebo: water; 
      GLN: water with 25 g maltodextrine plus 10 g GLN; and CHO: water with 25 g 
      maltodextrine) before anesthesia. Blood samples were collected pre- and 
      postoperatively. RESULTS: The mean (SEM) postoperative homeostasis model 
      assessment-insulin resistance was greater (P < .05) in control patients (4.3 
      [1.3]) than in the other groups (placebo, 1.6 [0.3]; CHO, 2.3 [0.4]; and GLN, 1.5 
      [0.1]). Glutathione was significantly higher (P < .01) in the GLN group than in 
      both CHO and control groups. Interleukin-6 increased in all groups except the GLN 
      group. The C-reactive protein/albumin ratio was higher (P < .05) in controls than 
      in CHO and GLN groups. The nitrogen balance was less negative in GLN (-2.5 [0.8] 
      gN) than in both placebo (-9.0 [2] gN; P = .001) and control (-6.6 [0.4] gN; P = 
      .04) groups. CONCLUSIONS: Preoperative intake of a GLN-enriched CHO beverage 
      appears to improve IR and antioxidant defenses and decreases the inflammatory 
      response after video-cholecystectomy.
FAU - Dock-Nascimento, Diana Borges
AU  - Dock-Nascimento DB
AD  - Department of Food and Nutrition, Federal University of Mato Grosso, Cuiaba, 
      Brazil. dianadock@hotmail.com
FAU - de Aguilar-Nascimento, Jose Eduardo
AU  - de Aguilar-Nascimento JE
FAU - Magalhaes Faria, Marcelo Sepulveda
AU  - Magalhaes Faria MS
FAU - Caporossi, Cervantes
AU  - Caporossi C
FAU - Slhessarenko, Natasha
AU  - Slhessarenko N
FAU - Waitzberg, Dan Linetzky
AU  - Waitzberg DL
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-6)
RN  - 0 (Polysaccharides)
RN  - 0RH81L854J (Glutamine)
RN  - 7CVR7L4A2D (maltodextrin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - GAN16C9B8O (Glutathione)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Acute-Phase Reaction/*metabolism
MH  - Adult
MH  - Blood Glucose/analysis
MH  - C-Reactive Protein/analysis
MH  - Cholecystectomy, Laparoscopic/*methods
MH  - Fasting/*metabolism
MH  - Female
MH  - Glutamine/administration & dosage
MH  - Glutathione/*blood
MH  - Humans
MH  - *Insulin Resistance
MH  - Interleukin-6/blood
MH  - Middle Aged
MH  - Nitrogen/*blood
MH  - Polysaccharides/administration & dosage
MH  - Postoperative Period
MH  - Preoperative Care/methods
MH  - Young Adult
EDAT- 2012/01/12 06:00
MHDA- 2012/05/04 06:00
CRDT- 2012/01/12 06:00
PHST- 2012/01/12 06:00 [entrez]
PHST- 2012/01/12 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 36/1/43 [pii]
AID - 10.1177/0148607111422719 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2012 Jan;36(1):43-52. doi: 
      10.1177/0148607111422719.