PMID- 22237898
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20211021
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 19
IP  - 3
DP  - 2012 Mar
TI  - Effects of North American porcine reproductive and respiratory syndrome virus 
      (PRRSV)-based modified live vaccines on preimmunized sows artificially 
      inseminated with European PRRSV-spiked semen.
PG  - 319-24
LID - 10.1128/CVI.05639-11 [doi]
AB  - The objective of the present study was to determine if the European porcine 
      reproductive and respiratory syndrome virus (PRRSV) can be transmitted via spiked 
      semen to preimmunized sows and induce reproductive failure. Sows were immunized 
      with the North American PRRSV-based modified live vaccine (Ingelvac PRRS MLV; 
      Boehringer Ingelheim Animal Health, St. Joseph, MO) and were artificially 
      inseminated. The sows were randomly divided into three groups. The vaccinated 
      (group 2) and nonvaccinated (group 3) sows developed a PRRSV viremia at 7 to 28 
      days postinsemination with the European PRRSV-spiked semen. The number of genomic 
      copies of the European PRRSV in serum samples was not significantly different 
      between vaccinated and nonvaccinated sows. All negative-control sows in group 1 
      farrowed at the expected date. The sows in groups 2 and 3 farrowed between 103 
      and 110 days after the first insemination. European PRRSV RNA was detected in the 
      lungs of 8 out of 11 live-born piglets and 46 out of 54 stillborn fetuses. In 
      addition, PRRSV RNA was detected using in situ hybridization in other tissues 
      from vaccinated sows that had been inseminated with European PRRSV-spiked semen 
      (group 2). The present study has demonstrated that vaccinating sows with the 
      North American PRRSV-based modified live vaccine does not prevent reproductive 
      failure after insemination with European PRRSV-spiked semen.
FAU - Han, Kiwon
AU  - Han K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Republic of Korea.
FAU - Seo, Hwi Won
AU  - Seo HW
FAU - Oh, Yeonsu
AU  - Oh Y
FAU - Kang, Ikjae
AU  - Kang I
FAU - Park, Changhoon
AU  - Park C
FAU - Chae, Chanhee
AU  - Chae C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120111
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Blood/virology
MH  - Female
MH  - Lung/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control/transmission
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Semen/*virology
MH  - Swine
MH  - Vaccines, Attenuated/administration & dosage/genetics/immunology
MH  - Viral Load
MH  - Viral Vaccines/administration & dosage/genetics/*immunology
MH  - Viremia/prevention & control
PMC - PMC3294617
EDAT- 2012/01/13 06:00
MHDA- 2012/06/14 06:00
PMCR- 2012/09/01
CRDT- 2012/01/13 06:00
PHST- 2012/01/13 06:00 [entrez]
PHST- 2012/01/13 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - CVI.05639-11 [pii]
AID - 05639-11 [pii]
AID - 10.1128/CVI.05639-11 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2012 Mar;19(3):319-24. doi: 10.1128/CVI.05639-11. Epub 2012 
      Jan 11.