PMID- 22237931
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20240323
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 520
IP  - 11
DP  - 2012 Aug 1
TI  - (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression 
      of neurotrophins and their receptors in multiple regions of adult rat brain.
PG  - 2459-74
LID - 10.1002/cne.23048 [doi]
AB  - (+/-)3,4-Methylenedioxymethamphetamine (MDMA), a widely used drug of abuse, rapidly 
      reduces serotonin levels in the brain when ingested or administered in sufficient 
      quantities, resulting in deficits in complex route-based learning, spatial 
      learning, and reference memory. Neurotrophins are important for survival and 
      preservation of neurons in the adult brain, including serotonergic neurons. In 
      this study, we examined the effects of MDMA on the expression of brain-derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their respective 
      high-affinity receptors, tropomyosin receptor kinase (trk)B and trkC, in multiple 
      regions of the rat brain. A serotonergic-depleting dose of MDMA (10 mg/kg x 4 at 
      2-hour intervals on a single day) was administered to adult Sprague-Dawley rats, 
      and brains were examined 1, 7, or 24 hours after the last dose. Messenger RNA 
      levels of BDNF, NT-3, trkB, and trkC were analyzed by using in situ hybridization 
      with cRNA probes. The prefrontal cortex was particularly vulnerable to 
      MDMA-induced alterations in that BDNF, NT-3, trkB, and trkC mRNAs were all 
      upregulated at multiple time points. MDMA-treated animals had increased BDNF 
      expression in the frontal, parietal, piriform, and entorhinal cortices, increased 
      NT-3 expression in the anterior cingulate cortex, and elevated trkC in the 
      entorhinal cortex. In the nigrostriatal system, BDNF expression was upregulated 
      in the substantia nigra pars compacta, and trkB was elevated in the striatum in 
      MDMA-treated animals. Both neurotrophins and trkB were differentially regulated 
      in several regions of the hippocampal formation. These findings suggest a 
      possible role for neurotrophin signaling in the learning and memory deficits seen 
      following MDMA treatment.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Hemmerle, Ann M
AU  - Hemmerle AM
AD  - Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio 45267, 
      USA.
FAU - Dickerson, Jonathan W
AU  - Dickerson JW
FAU - Herring, Nicole R
AU  - Herring NR
FAU - Schaefer, Tori L
AU  - Schaefer TL
FAU - Vorhees, Charles V
AU  - Vorhees CV
FAU - Williams, Michael T
AU  - Williams MT
FAU - Seroogy, Kim B
AU  - Seroogy KB
LA  - eng
GR  - NS39128/NS/NINDS NIH HHS/United States
GR  - DA14269/DA/NIDA NIH HHS/United States
GR  - K01 DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA021394/DA/NIDA NIH HHS/United States
GR  - DA021394/DA/NIDA NIH HHS/United States
GR  - R01 NS039128/NS/NINDS NIH HHS/United States
GR  - T32 ES007051/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hallucinogens)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Agents)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain-Derived Neurotrophic Factor/*drug effects/genetics/metabolism
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Corticosterone/blood
MH  - Hallucinogens/*pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neostriatum/drug effects/metabolism
MH  - Neurotrophin 3/*drug effects/genetics/metabolism
MH  - RNA, Messenger/analysis
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/drug effects/genetics/metabolism
MH  - Receptor, trkC/drug effects/genetics/metabolism
MH  - Serotonin Agents/pharmacology
MH  - Substantia Nigra/drug effects/metabolism
MH  - Time Factors
MH  - Tyrosine 3-Monooxygenase/drug effects/metabolism
PMC - PMC3891916
MID - NIHMS542092
EDAT- 2012/01/13 06:00
MHDA- 2012/09/29 06:00
PMCR- 2014/01/15
CRDT- 2012/01/13 06:00
PHST- 2012/01/13 06:00 [entrez]
PHST- 2012/01/13 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
PHST- 2014/01/15 00:00 [pmc-release]
AID - 10.1002/cne.23048 [doi]
PST - ppublish
SO  - J Comp Neurol. 2012 Aug 1;520(11):2459-74. doi: 10.1002/cne.23048.