PMID- 22238253
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20211021
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Print)
IS  - 2151-464X (Linking)
VI  - 64
IP  - 5
DP  - 2012 May
TI  - Inactive disease and remission in childhood-onset systemic lupus erythematosus.
PG  - 683-93
LID - 10.1002/acr.21612 [doi]
AB  - OBJECTIVE: To define inactive disease (ID) and clinical remission (CR) and to 
      delineate variables that can be used to measure ID/CR in childhood-onset systemic 
      lupus erythematosus (cSLE). METHODS: Delphi questionnaires were sent to an 
      international group of pediatric rheumatologists. Respondents provided 
      information about variables to be used in future algorithms to measure ID/CR. The 
      usefulness of these variables was assessed in 35 children with ID and 31 children 
      with minimally active lupus (MAL). RESULTS: While ID reflects cSLE status at a 
      specific point in time, CR requires the presence of ID for >6 months and 
      considers treatment. There was consensus that patients in ID/CR can have <2 mild 
      nonlimiting symptoms (i.e., fatigue, arthralgia, headaches, or myalgia) but not 
      Raynaud's phenomenon, chest pain, or objective physical signs of cSLE; 
      antinuclear antibody positivity and erythrocyte sedimentation rate elevation can 
      be present. Complete blood count, renal function testing, and complement C3 all 
      must be within the normal range. Based on consensus, only damage-related 
      laboratory or clinical findings of cSLE are permissible with ID. The above 
      parameters were suitable to differentiate children with ID/CR from those with MAL 
      (area under the receiver operating characteristic curve >0.85). Disease activity 
      scores with or without the physician global assessment of disease activity and 
      patient symptoms were well suited to differentiate children with ID from those 
      with MAL. CONCLUSION: Consensus has been reached on common definitions of ID/CR 
      with cSLE and relevant patient characteristics with ID/CR. Further studies must 
      assess the usefulness of the data-driven candidate criteria for ID in cSLE.
CI  - Copyright (c) 2012 by the American College of Rheumatology.
FAU - Mina, Rina
AU  - Mina R
AD  - Cincinnati Children's Hospital Medical Center, University of Cincinnati, William 
      S. Rowe Division of Rheumatology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, 
      USA.
FAU - Klein-Gitelman, Marisa S
AU  - Klein-Gitelman MS
FAU - Ravelli, Angelo
AU  - Ravelli A
FAU - Beresford, Michael W
AU  - Beresford MW
FAU - Avcin, Tadej
AU  - Avcin T
FAU - Espada, Graciela
AU  - Espada G
FAU - Eberhard, B Anne
AU  - Eberhard BA
FAU - Schanberg, Laura E
AU  - Schanberg LE
FAU - O'Neil, Kathleen M
AU  - O'Neil KM
FAU - Silva, Clovis A
AU  - Silva CA
FAU - Higgins, Gloria C
AU  - Higgins GC
FAU - Onel, Karen
AU  - Onel K
FAU - Singer, Nora G
AU  - Singer NG
FAU - von Scheven, Emily
AU  - von Scheven E
FAU - Imundo, Lisa F
AU  - Imundo LF
FAU - Nelson, Shannen
AU  - Nelson S
FAU - Giannini, Edward H
AU  - Giannini EH
FAU - Brunner, Hermine I
AU  - Brunner HI
LA  - eng
GR  - U01 AR059509-02/AR/NIAMS NIH HHS/United States
GR  - P60 AR047784-06A2/AR/NIAMS NIH HHS/United States
GR  - U01 AR059509-03/AR/NIAMS NIH HHS/United States
GR  - U01 AR055054-01/AR/NIAMS NIH HHS/United States
GR  - U01 AR051868/AR/NIAMS NIH HHS/United States
GR  - U01 AR051868-03/AR/NIAMS NIH HHS/United States
GR  - P60 AR047784-09/AR/NIAMS NIH HHS/United States
GR  - P60 AR047784-07/AR/NIAMS NIH HHS/United States
GR  - U01 AR059509/AR/NIAMS NIH HHS/United States
GR  - P60-AR047884/AR/NIAMS NIH HHS/United States
GR  - R01 AR051868-01/AR/NIAMS NIH HHS/United States
GR  - P30-AR AR47363/AR/NIAMS NIH HHS/United States
GR  - U01 AR055054-03S1/AR/NIAMS NIH HHS/United States
GR  - P60 AR047784-08/AR/NIAMS NIH HHS/United States
GR  - R01 AR051868/AR/NIAMS NIH HHS/United States
GR  - U01 AR055054-03/AR/NIAMS NIH HHS/United States
GR  - U01 AR055054/AR/NIAMS NIH HHS/United States
GR  - U01-AR51868/AR/NIAMS NIH HHS/United States
GR  - T32100291/PHS HHS/United States
GR  - U01 AR055054-02/AR/NIAMS NIH HHS/United States
GR  - U01 AR059509-01/AR/NIAMS NIH HHS/United States
GR  - P60 AR047784/AR/NIAMS NIH HHS/United States
GR  - P30 AR047363/AR/NIAMS NIH HHS/United States
GR  - U01 AR051868-02/AR/NIAMS NIH HHS/United States
GR  - UL1 RR026314/RR/NCRR NIH HHS/United States
GR  - UL1RR026314/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Female
MH  - Health Surveys/methods
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*pathology/*therapy
MH  - Male
MH  - Remission Induction/methods
MH  - *Severity of Illness Index
PMC - PMC3336032
MID - NIHMS349088
EDAT- 2012/01/13 06:00
MHDA- 2012/05/18 06:00
PMCR- 2013/05/01
CRDT- 2012/01/13 06:00
PHST- 2012/01/13 06:00 [entrez]
PHST- 2012/01/13 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - 10.1002/acr.21612 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2012 May;64(5):683-93. doi: 10.1002/acr.21612.