PMID- 22239965
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20120220
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 417-418
DP  - 2012 Feb 15
TI  - Transfer of PBDEs and chlorinated POPs from mother to pup during lactation in 
      harp seals Phoca groenlandica.
PG  - 98-107
LID - 10.1016/j.scitotenv.2011.11.084 [doi]
AB  - Seven mother-pup pairs of harp seal (Phoca groenlandica) were sampled during the 
      lactation season near Magdalen Islands, QC, Canada. The blubber and serum of pups 
      and mothers as well as the milk of mothers were analyzed for polybrominated 
      diphenyl ethers and several chlorinated persistent organic pollutants (POPs) to 
      evaluate their transfer prior to weaning. Principal component analysis 
      demonstrated significant variations in contaminant distribution patterns between 
      seal tissues of mothers and pups. The selectivity in the transfer of POPs between 
      mothers and pups appeared mainly driven by their log K(ow) (octanol/water 
      partition coefficient). The most selective transfer step for the POPs examined 
      occurred between the blubber and the serum of the mother. A novel approach to 
      examine temporal changes of POP concentrations in tissues of seals which take 
      into account the contamination of mothers was developed. A general decrease of 
      POP concentrations in pup tissues throughout lactation may suggest a growth 
      dilution. A concomitant rise of POP concentrations was observed in maternal 
      blubber and serum and in milk as lactation progresses. The intensive offloading 
      of contaminants via lactation constitutes a major but selective excretory route 
      for reproductive female seals and also a significant route of exposure for 
      suckling pup seals.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Frouin, Heloise
AU  - Frouin H
AD  - Institut National de la Recherche Scientifique - Institut Armand-Frappier, Laval, 
      Quebec, Canada H7V 1B7. heloise.frouin@gmail.com
FAU - Lebeuf, Michel
AU  - Lebeuf M
FAU - Hammill, Mike
AU  - Hammill M
FAU - Fournier, Michel
AU  - Fournier M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120110
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adipose Tissue/chemistry/*metabolism
MH  - Animals
MH  - Animals, Suckling
MH  - Biopsy
MH  - Environmental Pollutants/blood/*pharmacokinetics
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood/*pharmacokinetics
MH  - Hydrocarbons, Chlorinated/blood/*pharmacokinetics
MH  - Lactation/*physiology
MH  - Milk/chemistry/*metabolism
MH  - Principal Component Analysis
MH  - Quebec
MH  - Seals, Earless/blood/*metabolism
MH  - Time Factors
EDAT- 2012/01/14 06:00
MHDA- 2012/06/22 06:00
CRDT- 2012/01/14 06:00
PHST- 2011/09/01 00:00 [received]
PHST- 2011/11/25 00:00 [revised]
PHST- 2011/11/30 00:00 [accepted]
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - S0048-9697(11)01402-1 [pii]
AID - 10.1016/j.scitotenv.2011.11.084 [doi]
PST - ppublish
SO  - Sci Total Environ. 2012 Feb 15;417-418:98-107. doi: 
      10.1016/j.scitotenv.2011.11.084. Epub 2012 Jan 10.