PMID- 22240102
OWN - NLM
STAT- MEDLINE
DCOM- 20130125
LR  - 20181201
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 509
IP  - 2
DP  - 2012 Feb 16
TI  - Lateral hypothalamic area mediated the aggravated effect of microinjection of 
      Baclofen into cerebellar fastigial nucleus on stress gastric mucosal damage in 
      rats.
PG  - 125-9
LID - 10.1016/j.neulet.2011.12.057 [doi]
AB  - Cerebellum, primarily believed as a subcortical somatic motor center, is 
      increasingly considered to be implicated in visceral activities. However, little 
      is known about its regulation on gastrointestinal organs. In this research, we 
      investigated the aggravated effect of microinjection of gamma-aminobutyric acid 
      receptor subtype B (GABA(B)R) agonist, Baclofen into cerebellar fastigial nucleus 
      (FN) on stress gastric mucosal damage (SGMD) and its possible regulatory 
      mechanism. The gastric mucosal damage index was chosen to indicate the severity 
      of gastric mucosal injure. Immunohistochemistry and transferase-mediated 
      dUTP-biotin nick-endlabeling (TUNEL) methods were used to detect the variations 
      of lateral hypothalamic area (LHA) and gastric mucosa. It had been demonstrated 
      that FN participates in regulation of SGMD via its GABA(B)R and GABA neural 
      pathway, which passes through the decussation of superior cerebellar peduncle and 
      projects to the GABA receptors in LHA. Meanwhile, celiac sympathetic nerve 
      involves in this process via mediating neural discharge, which results in the 
      decrease of gastric mucosal blood flow. Additionally, apoptosis, proliferation 
      and oxidation in gastric mucosa, and gastric acid contribute in the mechanism. It 
      could be expected that these results might suggest insights to the cerebellar and 
      hypothalamic function, and the treatment of gastrointestinal diseases.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhu, Jin-Zhou
AU  - Zhu JZ
AD  - Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical College, 99 
      West Huaihai Road, Xuzhou, 221002 Jiangsu, China.
FAU - Fei, Su-Juan
AU  - Fei SJ
FAU - Zhang, Jian-Fu
AU  - Zhang JF
FAU - Zhu, Sheng-Ping
AU  - Zhu SP
FAU - Liu, Zhang-Bo
AU  - Liu ZB
FAU - Li, Ting-Ting
AU  - Li TT
FAU - Qiao, Xiao
AU  - Qiao X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120105
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (GABA-B Receptor Agonists)
RN  - 0 (Receptors, GABA)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - H789N3FKE8 (Baclofen)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Baclofen/administration & dosage/*pharmacology
MH  - Cell Proliferation/drug effects
MH  - Cerebellar Nuclei/*drug effects/*physiology
MH  - GABA-B Receptor Agonists/administration & dosage/pharmacology
MH  - Ganglia, Sympathetic/physiology/surgery
MH  - Ganglionectomy
MH  - Gastric Acid/metabolism
MH  - Gastric Mucosa/drug effects/*innervation/*pathology
MH  - Gastrointestinal Diseases/physiopathology
MH  - Hypothalamic Area, Lateral/*drug effects/*physiology
MH  - Microinjections
MH  - Neural Pathways/drug effects
MH  - Rats
MH  - Receptors, GABA/metabolism
MH  - Stress, Physiological/*physiology
MH  - gamma-Aminobutyric Acid/metabolism
EDAT- 2012/01/14 06:00
MHDA- 2013/01/26 06:00
CRDT- 2012/01/14 06:00
PHST- 2011/11/03 00:00 [received]
PHST- 2011/12/27 00:00 [revised]
PHST- 2011/12/28 00:00 [accepted]
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2013/01/26 06:00 [medline]
AID - S0304-3940(12)00002-X [pii]
AID - 10.1016/j.neulet.2011.12.057 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Feb 16;509(2):125-9. doi: 10.1016/j.neulet.2011.12.057. Epub 
      2012 Jan 5.