PMID- 22240432
OWN - NLM
STAT- MEDLINE
DCOM- 20120502
LR  - 20221207
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Jan 12
TI  - The MCP-1 (CCL2) -2518 GG genotype is associated with protection against 
      pulmonary tuberculosis in Moroccan patients.
PG  - 73-8
AB  - INTRODUCTION: Both monocyte chemoattractant protein-1 (MCP-1), also designated 
      officially as chemokine (C-C motif) ligand 2 (CCL2), and interleukin-12 p40 
      (IL-12 p40) molecules, encoded by polymorphic genes, are central components of 
      the immune response to infection by Mycobacterium tuberculosis (Mtb). Their 
      genetic diversity has previously been associated with the outcome of tuberculosis 
      (TB) infection. We investigated whether the MCP-1 -2518 A/G and the IL-12B (p40) 
      +1188 A/C polymorphisms influence susceptibility to or resistance against 
      pulmonary tuberculosis (PTB) in a Moroccan population group. METHODOLOGY: Genomic 
      DNA from 337 patients along with 204 healthy controls were genotyped for the 
      above-mentioned genetic variations using polymerase chain reaction-based 
      restriction fragment length polymorphism assay. RESULTS: We found a higher 
      prevalence of homozygous MCP-1 -2518 G allele in healthy individuals than in 
      patients (pc = 0.04; odds ratio  = 0.35; 95% confidence interval  = 0.13 - 0.86), 
      suggesting a potential protective effect, whereas analysis of IL-12B +1188 
      variation failed to reveal any such association. CONCLUSION: Our results are in 
      agreement with recent findings in Ghanaian patients, complying with the known 
      genetic admixture of the Moroccan population.
FAU - Arji, Naima
AU  - Arji N
AD  - Immunology and Virology Department, National Institute of Hygiene, Agdal, Rabat, 
      Morocco. arjinaima@yahoo.fr
FAU - Busson, Marc
AU  - Busson M
FAU - Iraqi, Ghali
AU  - Iraqi G
FAU - Bourkadi, Jamal Eddine
AU  - Bourkadi JE
FAU - Benjouad, Abdelaziz
AU  - Benjouad A
FAU - Boukouaci, Wahid
AU  - Boukouaci W
FAU - Lahlou, Ouafae
AU  - Lahlou O
FAU - Ben Amor, Jouda
AU  - Ben Amor J
FAU - Krishnamoorthy, Rajagopal
AU  - Krishnamoorthy R
FAU - Charron, Dominique
AU  - Charron D
FAU - El Aouad, Rajae
AU  - El Aouad R
FAU - Tamouza, Ryad
AU  - Tamouza R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120112
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL12B protein, human)
RN  - 0 (Interleukin-12 Subunit p40)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Black People/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-12 Subunit p40/*genetics
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - Mycobacterium tuberculosis/pathogenicity
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Tuberculosis, Pulmonary/epidemiology/ethnology/*genetics/microbiology
MH  - Young Adult
EDAT- 2012/01/14 06:00
MHDA- 2012/05/04 06:00
CRDT- 2012/01/14 06:00
PHST- 2011/02/18 00:00 [received]
PHST- 2011/06/25 00:00 [accepted]
PHST- 2011/05/24 00:00 [revised]
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 10.3855/jidc.1925 [doi]
PST - epublish
SO  - J Infect Dev Ctries. 2012 Jan 12;6(1):73-8. doi: 10.3855/jidc.1925.