PMID- 22243700
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20240322
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 11
DP  - 2012 Jan 13
TI  - beta-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct 
      hypocholesterolemic effects in rats.
PG  - 11
LID - 10.1186/1476-511X-11-11 [doi]
AB  - BACKGROUND: There is increasing interest in non-pharmacological control of 
      cholesterol and triglyceride levels in the plasma and diet-drug association 
      represent an important area of studies. The objective of this study was to 
      observe the hypocholesterolemic effect of soybean beta-conglycinin (7S protein) 
      alone and combined with fenofibrate and rosuvastatin, two hypolipidemic drugs. 
      METHODS: The protein and drugs were administered orally once a day to rats and 
      the effects were evaluated after 28 days. Wistar rats were divided into six 
      groups (n = 9): hypercholesterolemic diet (HC), HC+7S protein (300 mg.kg-1 day-1) 
      (HC-7S), HC+fenofibrate (30 mg.kg-1 day-1)(HC-FF), HC+rosuvastatin (10 mg.kg-1 
      day-1)(HC-RO), HC+7S+fenofibrate (HC-7S-FF) and HC+7S+rosuvastatin (HC-7S-RO). 
      RESULTS: Animals in HC-7S, HC-FF and HC-RO exhibited reductions of 22.9, 35.8 and 
      18.8% in total plasma cholesterol, respectively. In HC-7S-FF, animals did not 
      show significant alteration of the level in HC+FF while the group HC-7S-RO showed 
      a negative effect in comparison with groups taking only protein (HC-7S) or drug 
      (HC-RO). The administration of the protein, fenofibrate and rosuvastatin alone 
      caused increases in the plasma HDL-C of the animals, while the protein-drug 
      combinations led to an increase compared to HC-FF and HC-RO. The plasma 
      concentration of triacylgycerides was significantly reduced in the groups without 
      association, while HC-7S-FF showed no alteration and HC-7S-RO a little reduction. 
      CONCLUSION: The results of our study indicate that conglycinin has effects 
      comparable to fenofibrate and rosuvastatin on the control of plasma cholesterol, 
      HDL-C and triacylglycerides, when given to hypercholesterolemic rats, and 
      suggests that the association of this protein with rosuvastatin alters the action 
      of drug in the homeostasis of cholesterol.
FAU - Ferreira, Ederlan S
AU  - Ferreira ES
AD  - Department of Food and Nutrition, School of Pharmaceutical Sciences, Sao Paulo 
      State University -UNESP, Araraquara, SP, Brazil.
FAU - Silva, Maraiza A
AU  - Silva MA
FAU - Demonte, Aureluce
AU  - Demonte A
FAU - Neves, Valdir A
AU  - Neves VA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120113
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Antigens, Plant)
RN  - 0 (Dietary Proteins)
RN  - 0 (Drug Combinations)
RN  - 0 (Fluorobenzenes)
RN  - 0 (Globulins)
RN  - 0 (Pyrimidines)
RN  - 0 (Seed Storage Proteins)
RN  - 0 (Soybean Proteins)
RN  - 0 (Sulfonamides)
RN  - 0 (Triglycerides)
RN  - 0 (beta-conglycinin protein, Glycine max)
RN  - 83MVU38M7Q (Rosuvastatin Calcium)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - U202363UOS (Fenofibrate)
SB  - IM
MH  - Animals
MH  - Anticholesteremic Agents/isolation & purification/*pharmacology/therapeutic use
MH  - Antigens, Plant/isolation & purification/*pharmacology/therapeutic use
MH  - Cholesterol/blood/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Dietary Proteins/isolation & purification/*pharmacology/therapeutic use
MH  - Drug Combinations
MH  - Drug Synergism
MH  - Fenofibrate/*pharmacology/therapeutic use
MH  - Fluorobenzenes/*pharmacology/therapeutic use
MH  - Globulins/isolation & purification/*pharmacology/therapeutic use
MH  - Heart/drug effects
MH  - Hypercholesterolemia/blood/drug therapy/etiology
MH  - Liver/drug effects/metabolism/pathology
MH  - Male
MH  - Myocardium/pathology
MH  - Organ Size/drug effects
MH  - Pyrimidines/*pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Rosuvastatin Calcium
MH  - Seed Storage Proteins/isolation & purification/*pharmacology/therapeutic use
MH  - Soybean Proteins/isolation & purification/*pharmacology/therapeutic use
MH  - *Glycine max
MH  - Sulfonamides/*pharmacology/therapeutic use
MH  - Triglycerides/blood/metabolism
PMC - PMC3285525
EDAT- 2012/01/17 06:00
MHDA- 2012/05/18 06:00
PMCR- 2012/01/13
CRDT- 2012/01/17 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2012/01/13 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
PHST- 2012/01/13 00:00 [pmc-release]
AID - 1476-511X-11-11 [pii]
AID - 10.1186/1476-511X-11-11 [doi]
PST - epublish
SO  - Lipids Health Dis. 2012 Jan 13;11:11. doi: 10.1186/1476-511X-11-11.