PMID- 22244477
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20221207
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 167
IP  - 2
DP  - 2013 Jul 31
TI  - Impact of elevated serum glycated albumin levels on contrast-induced acute kidney 
      injury in diabetic patients with moderate to severe renal insufficiency 
      undergoing coronary angiography.
PG  - 369-73
LID - S0167-5273(11)02282-0 [pii]
LID - 10.1016/j.ijcard.2011.12.101 [doi]
AB  - BACKGROUND: Glycated albumin (GA) has been shown to be a better indicator than 
      glycosylated hemoglobin A1c (HbA1c) in terms of severity of renal impairment in 
      patients with type 2 diabetes mellitus (T2DM). This study aimed to determine 
      whether elevated serum GA levels are associated with an increased risk for 
      contrast-induced acute kidney injury (CI-AKI) and worse clinical outcome in 
      patients with T2DM and at least moderate renal insufficiency (RI) undergoing 
      coronary angiography. METHODS: Serum levels of fasting blood glucose (FBG), HbA1c 
      and GA were measured in 1030 patients with T2DM and moderate to severe RI (eGFR 
      15-59 mL/min/1.73 m(2)). CI-AKI was defined as >/= 25% increase in serum creatinine 
      within 72 h after the procedure. Receiver-operating characteristic curve was 
      constructed to assess the predictive value of GA, HbA1c and FBG for CI-AKI. 
      Multivariable logistic regression model was developed to identify risk factors 
      for CI-AKI, and Kaplan-Meier curve analysis was used to compare the rates of 
      dialysis and major adverse cardiac events (MACE) during one-year follow-up. 
      RESULTS: The overall rate of CI-AKI was 11.1%. GA was significantly higher in 
      patients with CI-AKI than in those without, and correlated positively with 
      changes of renal function after the procedure. After adjusting for age, sex, left 
      ventricular ejection fraction, multi-vessel disease, type and volume of contrast 
      media, FBG, and HbA1c, GA remained an independent risk factor for CI-AKI. GA >/= 
      21% was associated with increased rates of dialysis and MACE during one-year 
      follow-up in patients with or without CI-AKI. CONCLUSIONS: Increased GA level 
      serves as a valuable risk factor for CI-AKI and indicates poor one-year clinical 
      outcome in patients with T2DM and moderate to severe RI.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Ding, Feng Hua
AU  - Ding FH
AD  - Department of Cardiology, Rui Jin Hospital, Jiao Tong University School of 
      Medicine, Shanghai 200025, People's Republic of China.
FAU - Lu, Lin
AU  - Lu L
FAU - Zhang, Rui Yan
AU  - Zhang RY
FAU - Zhu, Tian Qi
AU  - Zhu TQ
FAU - Pu, Li Jin
AU  - Pu LJ
FAU - Zhang, Qi
AU  - Zhang Q
FAU - Chen, Qiu Jing
AU  - Chen QJ
FAU - Hu, Jian
AU  - Hu J
FAU - Yang, Zhen Kun
AU  - Yang ZK
FAU - Shen, Wei Feng
AU  - Shen WF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120114
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Acute Kidney Injury/*blood/chemically induced/diagnostic imaging
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Contrast Media/*adverse effects
MH  - Coronary Angiography/*adverse effects
MH  - Diabetes Mellitus, Type 2/*blood/diagnostic imaging
MH  - Female
MH  - Follow-Up Studies
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Renal Insufficiency/*blood/diagnostic imaging
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serum Albumin/*metabolism
MH  - Severity of Illness Index
MH  - Glycated Serum Albumin
EDAT- 2012/01/17 06:00
MHDA- 2014/02/25 06:00
CRDT- 2012/01/17 06:00
PHST- 2011/09/15 00:00 [received]
PHST- 2011/12/12 00:00 [revised]
PHST- 2011/12/25 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - S0167-5273(11)02282-0 [pii]
AID - 10.1016/j.ijcard.2011.12.101 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Jul 31;167(2):369-73. doi: 10.1016/j.ijcard.2011.12.101. Epub 
      2012 Jan 14.