PMID- 22244920
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 4
DP  - 2012 Apr
TI  - Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic 
      patients.
PG  - 426-31
LID - 10.1016/j.humimm.2011.12.019 [doi]
AB  - Shellfish allergy affects approximately 2% of the population and can cause 
      immediate hypersensitivity reactions such as urticaria, swelling, difficulty 
      breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp 
      allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic 
      patients and 20 negative control subjects were recruited and evaluated on the 
      basis of history, skin prick testing, specific immunoglobulin E (IgE) levels, and 
      peripheral blood mononuclear cell proliferation in response to shrimp tropomyosin 
      or shrimp tropomyosin-derived peptides. Of the classically allergic patients by 
      history, 59% tested positive for serum shrimp IgE antibodies. Of patients with 
      shrimp-specific IgE in sera, 70% also had significant IgE levels specific for 
      shrimp tropomyosin. Peripheral blood mononuclear cells from classically 
      shrimp-allergic patients proliferated in a dose-dependent manner in response to 
      to tropomyosin. In addition, a T-cell line derived from a shrimp-allergic patient 
      proliferated specifically in response to tropomyosin-derived peptides. These 
      studies suggest a strategy for immunotherapy using a tropomyosin-derived T-cell 
      epitope vaccination.
CI  - Published by Elsevier Inc.
FAU - Wang, Shuping
AU  - Wang S
AD  - Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
FAU - Delgado, Julio C
AU  - Delgado JC
FAU - Ravkov, Eugene
AU  - Ravkov E
FAU - Eckels, David D
AU  - Eckels DD
FAU - Georgelas, Ann
AU  - Georgelas A
FAU - Pavlov, Igor Y
AU  - Pavlov IY
FAU - Cusick, Matthew
AU  - Cusick M
FAU - Sebastian, Kate
AU  - Sebastian K
FAU - Gleich, Gerald J
AU  - Gleich GJ
FAU - Wagner, Lori A
AU  - Wagner LA
LA  - eng
GR  - R03 AI076386-02/AI/NIAID NIH HHS/United States
GR  - 5R03AI076386-02/AI/NIAID NIH HHS/United States
GR  - R21AI088589/AI/NIAID NIH HHS/United States
GR  - R03 AI076386-01/AI/NIAID NIH HHS/United States
GR  - R03 AI076386/AI/NIAID NIH HHS/United States
GR  - R21 AI088589/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111228
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Allergens)
RN  - 0 (Peptides)
RN  - 0 (Tropomyosin)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Amino Acid Sequence
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cell Line
MH  - Food Hypersensitivity/diagnosis/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Lymphocyte Activation/*immunology
MH  - Molecular Sequence Data
MH  - Penaeidae/*immunology
MH  - Peptides/chemistry/immunology
MH  - Skin Tests
MH  - Tropomyosin/chemistry/*immunology
PMC - PMC3319724
MID - NIHMS363469
EDAT- 2012/01/17 06:00
MHDA- 2012/07/28 06:00
PMCR- 2013/04/01
CRDT- 2012/01/17 06:00
PHST- 2011/08/16 00:00 [received]
PHST- 2011/12/02 00:00 [revised]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - S0198-8859(11)00610-0 [pii]
AID - 10.1016/j.humimm.2011.12.019 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 Apr;73(4):426-31. doi: 10.1016/j.humimm.2011.12.019. Epub 2011 
      Dec 28.