PMID- 22245020
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20120312
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Mar
TI  - Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty.
PG  - 145-55
LID - 10.1016/j.molmed.2011.12.002 [doi]
AB  - Theoretical, desirable features of second-generation metal-on-metal (MoM) hip 
      prostheses have led to their widespread use. However, the bearing surfaces, 
      consisting of complex cobalt-chromium alloys, are subject to wear and the release 
      of cobalt and chromium (CoCr) nanoparticles. These nanoparticles can reduce 
      cellular viability, induce DNA damage, lead to chromosomal aberrations, and 
      possibly stimulate increased metal hypersensitivity. Clinically, the effects can 
      be both local (soft-tissue reactions) and systemic (arthroprosthetic cobaltism). 
      This review assesses the literature concerning the in vitro and in vivo 
      cytotoxic, genotoxic, and immunotoxic effects of CoCr wear particles, which is 
      increasingly important in view of the large number of MoM arthroplasties 
      performed.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Gill, Harinderjit S
AU  - Gill HS
AD  - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Surgery, 
      University of Oxford, Headington, Oxford OX3 7LD, UK.
FAU - Grammatopoulos, George
AU  - Grammatopoulos G
FAU - Adshead, Stephen
AU  - Adshead S
FAU - Tsialogiannis, Evagellos
AU  - Tsialogiannis E
FAU - Tsiridis, Eleftherios
AU  - Tsiridis E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120112
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Chromium Alloys)
SB  - IM
MH  - Animals
MH  - Arthroplasty, Replacement, Hip/*instrumentation
MH  - Chromium Alloys/*toxicity
MH  - Hip Prosthesis/*adverse effects
MH  - Humans
MH  - Immune System/*drug effects
MH  - Nanoparticles/*toxicity
EDAT- 2012/01/17 06:00
MHDA- 2012/06/30 06:00
CRDT- 2012/01/17 06:00
PHST- 2011/09/14 00:00 [received]
PHST- 2011/12/04 00:00 [revised]
PHST- 2011/12/08 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
AID - S1471-4914(11)00211-5 [pii]
AID - 10.1016/j.molmed.2011.12.002 [doi]
PST - ppublish
SO  - Trends Mol Med. 2012 Mar;18(3):145-55. doi: 10.1016/j.molmed.2011.12.002. Epub 
      2012 Jan 12.