PMID- 22245316
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20220318
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 33
IP  - 10
DP  - 2012 Oct
TI  - Whole brain N-acetylaspartate concentration is conserved throughout normal aging.
PG  - 2440-7
LID - 10.1016/j.neurobiolaging.2011.12.008 [doi]
AB  - We hypothesize that normal aging implies neuronal durability, reflected by 
      age-independent concentrations of their marker--the amino acid derivative 
      N-acetylaspartate (NAA). To test this, we obtained the whole-brain and whole-head 
      N-acetylaspartate concentrations (WBNAA and WHNAA) with proton magnetic resonance 
      (MR) spectroscopy; and the fractional brain parenchyma volume (fBPV)--a metric of 
      atrophy, by segmenting the magnetic resonance image (MRI) from 42 (18 male) 
      healthy young (31.9 +/- 5.8 years old) and 100 (64 male, 72.6 +/- 7.3 years old) 
      cognitively normal elderly. The 12.8 +/- 1.9 mM WBNAA of the young was not 
      significantly different from the 13.1 +/- 3.1 mM in the elderly (p > 0.05). In 
      contrast, both fBPV (87.3 +/- 4.7% vs. 74.8 +/- 4.8%) and WHNAA (11.1 +/- 1.7 mM vs. 
      9.8 +/- 2.4 mM) were significantly higher in the young (approximately 14%; p < 
      0.0001 for both). The similarity in mean WBNAA between 2 cohorts 4 decades of 
      normal aging apart suggests that neuronal integrity is maintained across the 
      lifespan. Clinically, WBNAA could be used as a marker for normal (hence, also 
      abnormal) brain aging. In contrast, WHNAA and fBPV seem age-related suggesting 
      that brain atrophy may occur without compromising the remaining tissue.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Wu, William E
AU  - Wu WE
AD  - Department of Radiology, New York University School of Medicine, New York, NY, 
      USA.
FAU - Gass, Achim
AU  - Gass A
FAU - Glodzik, Lidia
AU  - Glodzik L
FAU - Babb, James S
AU  - Babb JS
FAU - Hirsch, Jochen
AU  - Hirsch J
FAU - Sollberger, Marc
AU  - Sollberger M
FAU - Achtnichts, Lutz
AU  - Achtnichts L
FAU - Amann, Michael
AU  - Amann M
FAU - Monsch, Andreas U
AU  - Monsch AU
FAU - Gonen, Oded
AU  - Gonen O
LA  - eng
GR  - R01 NS050520-05/NS/NINDS NIH HHS/United States
GR  - R01 EB001015-16/EB/NIBIB NIH HHS/United States
GR  - R56 NS050520-06A1/NS/NINDS NIH HHS/United States
GR  - R01 EB001015/EB/NIBIB NIH HHS/United States
GR  - EB01015/EB/NIBIB NIH HHS/United States
GR  - R01 NS050520/NS/NINDS NIH HHS/United States
GR  - R01 AG022374/AG/NIA NIH HHS/United States
GR  - NS050520/NS/NINDS NIH HHS/United States
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - R01 AG012101/AG/NIA NIH HHS/United States
GR  - R56 NS050520/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120114
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Biomarkers)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 997-55-7 (N-acetylaspartate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*metabolism
MH  - Aspartic Acid/*analogs & derivatives/analysis/metabolism
MH  - Atrophy/metabolism
MH  - Biomarkers/analysis/metabolism
MH  - Brain/*metabolism/pathology
MH  - *Brain Chemistry
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Organ Size
PMC - PMC3328687
MID - NIHMS343196
COIS- Disclosure statement The authors state that there are no actual or potential 
      conflicts of interest related to this paper.
EDAT- 2012/01/17 06:00
MHDA- 2013/01/23 06:00
PMCR- 2013/10/01
CRDT- 2012/01/17 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/12/01 00:00 [revised]
PHST- 2011/12/03 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - S0197-4580(11)00540-9 [pii]
AID - 10.1016/j.neurobiolaging.2011.12.008 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2012 Oct;33(10):2440-7. doi: 
      10.1016/j.neurobiolaging.2011.12.008. Epub 2012 Jan 14.