PMID- 22246039
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20210202
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 119
IP  - 10
DP  - 2012 Mar 8
TI  - Chromosome aberrations detected by conventional karyotyping using novel mitogens 
      in chronic lymphocytic leukemia with "normal" FISH: correlations with 
      clinicobiologic parameters.
PG  - 2310-3
LID - 10.1182/blood-2011-11-395269 [doi]
AB  - It is unclear whether karyotype aberrations that occur in regions uncovered by 
      the standard fluorescence in situ hybridization (FISH) panel have prognostic 
      relevance in chronic lymphocytic leukemia (CLL). We evaluated the significance of 
      karyotypic aberrations in a learning cohort (LC; n = 64) and a validation cohort 
      (VC; n = 84) of patients with chronic lymphocytic leukemia with "normal" FISH. An 
      abnormal karyotype was found in 21.5% and 35.7% of cases in the LC and VC, 
      respectively, and was associated with a lower immunophenotypic score (P = .030 in 
      the LC, P = .035 in the VC), advanced stage (P = .040 in the VC), and need for 
      treatment (P = .002 in the LC, P = < .0001 in the VC). The abnormal karyotype 
      correlated with shorter time to first treatment and shorter survival in both the 
      LC and the VC, representing the strongest prognostic parameter. In patients with 
      chronic lymphocytic leukemia with normal FISH, karyotypic aberrations by 
      conventional cytogenetics with novel mitogens identify a subset of cases with 
      adverse prognostic features.
FAU - Rigolin, Gian Matteo
AU  - Rigolin GM
AD  - Section of Hematology, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, 
      University of Ferrara, Italy. rglgmt@unife.it
FAU - Cibien, Francesca
AU  - Cibien F
FAU - Martinelli, Sara
AU  - Martinelli S
FAU - Formigaro, Luca
AU  - Formigaro L
FAU - Rizzotto, Lara
AU  - Rizzotto L
FAU - Tammiso, Elisa
AU  - Tammiso E
FAU - Saccenti, Elena
AU  - Saccenti E
FAU - Bardi, Antonella
AU  - Bardi A
FAU - Cavazzini, Francesco
AU  - Cavazzini F
FAU - Ciccone, Maria
AU  - Ciccone M
FAU - Nichele, Ilaria
AU  - Nichele I
FAU - Pizzolo, Giovanni
AU  - Pizzolo G
FAU - Zaja, Francesco
AU  - Zaja F
FAU - Fanin, Renato
AU  - Fanin R
FAU - Galieni, Piero
AU  - Galieni P
FAU - Dalsass, Alessia
AU  - Dalsass A
FAU - Mestichelli, Francesca
AU  - Mestichelli F
FAU - Testa, Nicoletta
AU  - Testa N
FAU - Negrini, Massimo
AU  - Negrini M
FAU - Cuneo, Antonio
AU  - Cuneo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120113
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (CpG-ODN DSP30)
RN  - 0 (Interleukin-2)
RN  - 0 (Mitogens)
RN  - 0 (Oligonucleotides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Interleukin-2/pharmacology
MH  - Karyotype
MH  - Karyotyping/*methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/pathology
MH  - Male
MH  - Metaphase/drug effects/genetics
MH  - Middle Aged
MH  - Mitogens/pharmacology
MH  - Oligonucleotides/pharmacology
MH  - Prognosis
MH  - Survival Analysis
EDAT- 2012/01/17 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/17 06:00
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S0006-4971(20)45978-6 [pii]
AID - 10.1182/blood-2011-11-395269 [doi]
PST - ppublish
SO  - Blood. 2012 Mar 8;119(10):2310-3. doi: 10.1182/blood-2011-11-395269. Epub 2012 
      Jan 13.