PMID- 22247332
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20120402
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Apr
TI  - Role of autophagy in immunity and autoimmunity, with a special focus on systemic 
      lupus erythematosus.
PG  - 1400-12
LID - 10.1096/fj.11-194175 [doi]
AB  - Autophagy is a lysosome-mediated catabolic process that allows cells to degrade 
      unwanted cytoplasmic constituents and to recycle nutrients. Autophagy is also 
      involved in innate and adaptive immune responses, playing a key role in 
      interactions against microbes, in antigen processing for major histocompatibility 
      complex (MHC) presentation, and in lymphocyte development, survival, and 
      proliferation. Over recent years, perturbations in autophagy have been implicated 
      in a number of diseases, including autoimmunity. Systemic lupus erythematosus 
      (SLE) is a multifactorial disease characterized by autoimmune responses against 
      self-antigens generated by dying cells. Genome-wide association studies have 
      linked several single-nucleotide polymorphisms (SNPs) in the autophagy-related 
      gene Atg5 to SLE susceptibility. Loss of Atg5-dependent effects, including 
      clearance of dying cells and cell antigen presentation, might contribute to the 
      autoimmunity and inflammation associated with SLE. Moreover, activation of the 
      mammalian target of rapamycin (mTOR), a key player in the autophagy regulation, 
      has recently been demonstrated in SLE, confirming an altered autophagy pathway in 
      this disease. In the present review, we summarize the autophagy mechanisms, their 
      molecular regulation, and their relevance in immunity and autoimmunity. The 
      potential of targeting autophagy pathway in SLE, by developing innovative 
      therapeutic approaches, has finally been discussed.
FAU - Pierdominici, Marina
AU  - Pierdominici M
AD  - Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, 
      Italy.
FAU - Vomero, Marta
AU  - Vomero M
FAU - Barbati, Cristiana
AU  - Barbati C
FAU - Colasanti, Tania
AU  - Colasanti T
FAU - Maselli, Angela
AU  - Maselli A
FAU - Vacirca, Davide
AU  - Vacirca D
FAU - Giovannetti, Antonello
AU  - Giovannetti A
FAU - Malorni, Walter
AU  - Malorni W
FAU - Ortona, Elena
AU  - Ortona E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120112
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
SB  - IM
MH  - *Adaptive Immunity
MH  - Autoimmunity/*immunology
MH  - Autophagy/*immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Lupus Erythematosus, Systemic/*immunology/physiopathology
MH  - Lymphocytes/immunology
MH  - Phagocytes/immunology
EDAT- 2012/01/17 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/01/17 06:00
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - fj.11-194175 [pii]
AID - 10.1096/fj.11-194175 [doi]
PST - ppublish
SO  - FASEB J. 2012 Apr;26(4):1400-12. doi: 10.1096/fj.11-194175. Epub 2012 Jan 12.