PMID- 22248366
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20211021
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Jun
TI  - Treatment for Helicobacter pylori infection and risk of Parkinson's disease in 
      Denmark.
PG  - 864-9
LID - 10.1111/j.1468-1331.2011.03643.x [doi]
AB  - BACKGROUND AND PURPOSE: It has been speculated that gastrointestinal infection 
      with Helicobacter pylori (HP) contributes to the development of Parkinson's 
      disease (PD). We used nationwide Danish registers to investigate this hypothesis. 
      METHODS:  We identified 4484 patients with a first time PD diagnosis between 2001 
      and 2008 from the Danish National Patient Register (DNPR) and 22, 416 population 
      controls from the Danish Civil Registration System (CRS). Information on drug use 
      was obtained from the National Prescription Registry (NPR). We used logistic 
      regression to compute odds ratios (OR) for the association between treatment for 
      HP and risk of PD. RESULTS: Prescriptions for HP-eradication drugs and proton 
      pump inhibitors (PPI) 5 or more years prior to the diagnosis of PD were 
      associated with a 45% and 23% increase in PD risk, respectively. Hospitalizations 
      and outpatient visits for gastritis and peptic/duodenal ulcers, however, were not 
      associated with PD. CONCLUSIONS:   Our population-based study suggests that 
      chronic HP infections and/or gastritis contribute to PD or that these are 
      PD-related pathologies that precede motor symptoms.
CI  - (c) 2012 The Author(s). European Journal of Neurology (c) 2012 EFNS.
FAU - Nielsen, H H
AU  - Nielsen HH
AD  - Department of Neurology, Odense University Hospital, Odense, Denmark. 
      hhnielsen@health.sdu.dk
FAU - Qiu, J
AU  - Qiu J
FAU - Friis, S
AU  - Friis S
FAU - Wermuth, L
AU  - Wermuth L
FAU - Ritz, B
AU  - Ritz B
LA  - eng
GR  - P50 NS038367/NS/NINDS NIH HHS/United States
GR  - R01 ES013717/ES/NIEHS NIH HHS/United States
GR  - R01 ES013717-01A1/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120117
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Denmark/epidemiology
MH  - Female
MH  - Helicobacter Infections/diagnosis/*drug therapy/*epidemiology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*epidemiology/*etiology
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Risk
PMC - PMC3330170
MID - NIHMS343768
EDAT- 2012/01/18 06:00
MHDA- 2012/09/15 06:00
PMCR- 2013/06/01
CRDT- 2012/01/18 06:00
PHST- 2012/01/18 06:00 [entrez]
PHST- 2012/01/18 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.1111/j.1468-1331.2011.03643.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2012 Jun;19(6):864-9. doi: 10.1111/j.1468-1331.2011.03643.x. Epub 
      2012 Jan 17.