PMID- 22249792
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20240217
IS  - 1806-9460 (Electronic)
IS  - 1516-3180 (Print)
IS  - 1516-3180 (Linking)
VI  - 129
IP  - 6
DP  - 2011 Dec
TI  - Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) 
      expression simultaneously in invasive and in situ breast ductal carcinoma.
PG  - 371-9
LID - S1516-31802011000600002 [pii]
AB  - CONTEXT AND OBJECTIVE: Cyclooxygenase-2 (COX-2) and human epidermal growth factor 
      receptor type 2 (HER-2) are associated with tumorigenesis. Studies have shown 
      that HER-2 can regulate COX-2 expression. The aim of this study was to evaluate 
      the correlation between COX-2 and HER-2 expression in normal breast epithelium 
      and in ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) 
      present in the same breast. DESIGN AND SETTING: Cross-sectional study at the 
      Mastology Unit of the Department of Gynecology and Obstetrics, Santa Casa de 
      Misericordia de Sao Paulo Hospital. METHODS: COX-2 and HER-2 were detected using 
      immunohistochemistry on 100 tissue fragments. HER-2 > +2 was subjected to 
      fluorescence in situ hybridization (FISH). RESULTS: COX-2 expression was detected 
      in 87%, 85% and 75% of IDC, DCIS and normal epithelium, respectively. HER-2 
      expression was detected in 34% of IDC and 34% of DCIS. COX-2 in DCIS correlated 
      with HER-2 in IDC (P = 0.049) and DCIS (P = 0.049). COX-2 in normal epithelium 
      correlated with HER-2 in IDC (P = 0.046) and DCIS (P = 0.046). COX-2 in IDC was 
      not associated with HER-2 (P = 0.235). Comparison between COX-2 and HER-2 in DCIS 
      showed that there was a statistically significant difference with regard to 
      nuclear grades II and III and presence of comedonecrosis (P < 0.001). In IDC, 
      there was significant expression with nuclear grades II and III and histological 
      grade II (P < 0.001). CONCLUSIONS: Our findings provide evidence that HER-2 and 
      COX-2 regulate each other.
FAU - Lucarelli, Adrienne Pratti
AU  - Lucarelli AP
AD  - Department of Gynecology and Obstetrics, Santa Casa de Misericordia de Sao Paulo 
      Hospital, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, 
      Brazil. adrilucarelli@terra.com.br
FAU - Martins, Maria Marta
AU  - Martins MM
FAU - Montor, Wagner
AU  - Montor W
FAU - Oliveira, Vilmar
AU  - Oliveira V
FAU - Galvao, Maria Antonieta Longo
AU  - Galvao MA
FAU - Piato, Sebastiao
AU  - Piato S
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Sao Paulo Med J
JT  - Sao Paulo medical journal = Revista paulista de medicina
JID - 100897261
RN  - 0 (Neoplasm Proteins)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*enzymology/pathology
MH  - Carcinoma, Ductal, Breast/*enzymology/pathology
MH  - Carcinoma, Intraductal, Noninfiltrating/*enzymology/pathology
MH  - Cyclooxygenase 2/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Necrosis
MH  - Neoplasm Proteins/*metabolism
MH  - Receptor, ErbB-2/*metabolism
MH  - Up-Regulation
PMC - PMC10868924
COIS- Conflict of interest: None
EDAT- 2012/01/18 06:00
MHDA- 2012/08/01 06:00
PMCR- 2011/12/01
CRDT- 2012/01/18 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2012/01/18 06:00 [entrez]
PHST- 2012/01/18 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - S1516-31802011000600002 [pii]
AID - 10.1590/s1516-31802011000600002 [doi]
PST - ppublish
SO  - Sao Paulo Med J. 2011 Dec;129(6):371-9. doi: 10.1590/s1516-31802011000600002.