PMID- 22252095 OWN - NLM STAT- MEDLINE DCOM- 20120427 LR - 20220317 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 137 IP - 1-3 DP - 2012 Mar TI - Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. PG - 151-5 LID - 10.1016/j.jad.2011.12.034 [doi] AB - BACKGROUND: Despite the old Kraepelinean concept that bipolar disorder (BD) does not evolve with cognitive decline, the presence of cognitive impairment, especially executive dysfunction has been recognized in BD patients. Brain-derived neurotrophic factor (BDNF) and pro-inflammatory molecules are important contributors to the pathophysiology of BD, and imbalance in peripheral levels of these molecules may be implicated in the cognitive decline observed in BD patients. We aimed to investigate the executive performance of BD type I euthymic patients and its relation with the plasma levels of BDNF, TNF-alpha and its related soluble receptors (sTNFR1 and sTNFR2). METHODS: We evaluated executive functioning through the Frontal Assessment Battery (FAB). Plasma levels of BDNF, TNF-alpha, sTNFR1 and sTNFR2 were measured using enzyme-linked immunosorbent assay (ELISA) in 25 euthymic type I BD patients and 25 age and gender matched healthy controls. RESULTS: BD patients had an impairment in executive functioning (p<0.006), particularly sensitivity of interference (p=0.02), inhibitory control (p=0.02), and increased BDNF plasma levels (p=0.001) in comparison with controls. Plasma levels of TNF-alpha were correlated with inhibitory control in BD patients (rho=0.50, p=0.02) while motor programming was negatively correlated with sTNFR2 plasma levels (rho=-0.47, p=0.02) in controls. Executive function correlated with age and MMSE, but not with BDNF, neither was influenced by psychiatric and clinical comorbidities nor medications in use. CONCLUSION: BDNF is altered in BD but do not correlate with executive functioning. CI - Copyright (c) 2011 Elsevier B.V. All rights reserved. FAU - Barbosa, Izabela Guimaraes AU - Barbosa IG AD - Programa de Pos-Graduacao em Neurociencias, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. izabela.barbosa@kcl.ac.uk FAU - Rocha, Natalia Pessoa AU - Rocha NP FAU - Huguet, Rodrigo Barreto AU - Huguet RB FAU - Ferreira, Rodrigo A AU - Ferreira RA FAU - Salgado, Joao Vinicius AU - Salgado JV FAU - Carvalho, Livia A AU - Carvalho LA FAU - Pariante, Carmine M AU - Pariante CM FAU - Teixeira, Antonio Lucio AU - Teixeira AL LA - eng GR - G108/603/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120116 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Receptors, Tumor Necrosis Factor, Type I) RN - 0 (Receptors, Tumor Necrosis Factor, Type II) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Adult MH - Biomarkers/blood MH - Bipolar Disorder/*blood/*psychology MH - Brain-Derived Neurotrophic Factor/*blood MH - *Executive Function MH - Female MH - Humans MH - Male MH - Middle Aged MH - Receptors, Tumor Necrosis Factor, Type I/blood MH - Receptors, Tumor Necrosis Factor, Type II/blood MH - Tumor Necrosis Factor-alpha/*blood EDAT- 2012/01/19 06:00 MHDA- 2012/04/28 06:00 CRDT- 2012/01/19 06:00 PHST- 2011/05/13 00:00 [received] PHST- 2011/12/14 00:00 [revised] PHST- 2011/12/14 00:00 [accepted] PHST- 2012/01/19 06:00 [entrez] PHST- 2012/01/19 06:00 [pubmed] PHST- 2012/04/28 06:00 [medline] AID - S0165-0327(11)00797-X [pii] AID - 10.1016/j.jad.2011.12.034 [doi] PST - ppublish SO - J Affect Disord. 2012 Mar;137(1-3):151-5. doi: 10.1016/j.jad.2011.12.034. Epub 2012 Jan 16.