PMID- 2225413
OWN - NLM
STAT- MEDLINE
DCOM- 19901214
LR  - 20061115
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 82
IP  - 5 Suppl
DP  - 1990 Nov
TI  - Latissimus dorsi cardiomyoplasty in the treatment of patients with dilated 
      cardiomyopathy.
PG  - IV257-63
AB  - Stimulated skeletal muscle grafts have been proposed as a means to reinforce 
      ventricular wall in the treatment of severe myocardial failure. Latissimus dorsi 
      cardiomyoplasty was performed in 11 patients with advanced heart failure due to 
      cardiomyopathy who were in New York Heart Association (NYHA) class III or IV 
      despite maximal medical therapy. There were no operative deaths. Eight patients 
      were followed for a mean of 10.8 months. Two patients remain in muscle 
      conditioning protocol. One patient died with latissimus dorsi ischemia and 
      congestive heart failure. Four of the eight patients in long-term follow-up are 
      in NYHA class I, three in class II, and one in class III. At 3 months of 
      follow-up, rest radioisotopic left ventricular ejection fraction increased from 
      20.5 +/- 3.6% to 26.8 +/- 8.1% (p less than 0.01). Doppler-echocardiography 
      demonstrated that left ventricular segmental wall shortening improved from 11.3 
      +/- 2.5% to 16.5 +/- 3.9% (p less than 0.01) and left ventricular stroke volume 
      from 22.9 +/- 4.6 to 33.1 +/- 10 ml (p less than 0.01). Cardiopulmonary exercise 
      test showed that maximal oxygen consumption during treadmill test increased from 
      14.8 +/- 3.7 to 18.2 +/- 3.3 ml/kg.min (p less than 0.05). At 6 months of 
      follow-up, all the above values remained essentially unchanged. Furthermore, 
      nonsustained ventricular tachycardia was abolished without specific medical 
      therapy in four patients. Thus, cardiomyoplasty improves left ventricular 
      function, reverses congestive heart failure, and may improve long-term survival 
      in severe cardiomyopathies.
FAU - Moreira, L F
AU  - Moreira LF
AD  - Instituto do Coracao, Faculdade de Medicina, Universidade de Sao Paulo, Brazil.
FAU - Stolf, N A
AU  - Stolf NA
FAU - Bocchi, E A
AU  - Bocchi EA
FAU - Pereira-Barretto, A C
AU  - Pereira-Barretto AC
FAU - Meneghetti, J C
AU  - Meneghetti JC
FAU - Giorgi, M C
AU  - Giorgi MC
FAU - Moraes, A V
AU  - Moraes AV
FAU - Leite, J J
AU  - Leite JJ
FAU - da Luz, P L
AU  - da Luz PL
FAU - Jatene, A D
AU  - Jatene AD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Adult
MH  - Assisted Circulation/*methods
MH  - Cardiomyopathy, Dilated/*surgery
MH  - *Electric Stimulation Therapy
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Muscle Contraction/physiology
MH  - Myocardial Contraction/physiology
MH  - *Surgical Flaps
MH  - Time Factors
MH  - Ventricular Function, Left/physiology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - Circulation. 1990 Nov;82(5 Suppl):IV257-63.