PMID- 22256791
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20231213
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 79
IP  - 4
DP  - 2012 Apr
TI  - HLA-E polymorphisms in hematopoietic stem cell transplantation.
PG  - 287-90
LID - 10.1111/j.1399-0039.2011.01832.x [doi]
AB  - Human leukocyte antigen (HLA)-E is an inhibitory ligand of natural killer cells 
      and gamma/delta T-cells. Differential expression of HLA-E alleles on the cell surface has 
      been reported to influence outcome of hematopoietic stem cell transplantation 
      (HSCT). We performed HLA-E genotyping in 116 HSCT patients and their HLA-matched 
      unrelated donors. The impact of HLA-E genotypes on patient's overall survival 
      (OS), disease free survival (DFS), cumulative incidences for relapse, 
      transplant-related mortality (TRM) and acute graft vs host disease (aGvHD) was 
      assessed. Neither univariate nor multivariate analysis showed any influence of 
      HLA-E polymorphisms on the investigated endpoints of HSCT in our cohort. We could 
      not confirm any of the previous observations in our cohort and consider it 
      unlikely that HLA-E polymorphisms affect outcome of HSCT.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Furst, D
AU  - Furst D
AD  - Department of Transplantation Immunology, Institute for Clinical Transfusion 
      Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, 
      Baden-Wuerttemberg - Hessia, Ulm, Germany. d.fuerst@blutpspende.de
FAU - Bindja, J
AU  - Bindja J
FAU - Arnold, R
AU  - Arnold R
FAU - Herr, W
AU  - Herr W
FAU - Schwerdtfeger, R
AU  - Schwerdtfeger R
FAU - Muller, C H
AU  - Muller CH
FAU - Recker, K
AU  - Recker K
FAU - Schrezenmeier, H
AU  - Schrezenmeier H
FAU - Mytilineos, J
AU  - Mytilineos J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120118
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Disease-Free Survival
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Polymorphism, Genetic
MH  - Treatment Outcome
MH  - HLA-E Antigens
EDAT- 2012/01/20 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/01/20 06:00
PHST- 2012/01/20 06:00 [entrez]
PHST- 2012/01/20 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01832.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Apr;79(4):287-90. doi: 10.1111/j.1399-0039.2011.01832.x. 
      Epub 2012 Jan 18.