PMID- 22260073
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20120120
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 21
DP  - 2011 Nov
TI  - [Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous 
      cell carcinoma].
PG  - 966-9
AB  - OBJECTIVE: To examine the expression and clinical significance of the Stat3 and 
      Cyclin D1 in laryngeal squamous cell carcinoma (LSCC). METHOD: The expression of 
      Stat3 and Cyclin D1 in LSCC tissue were detected by the RT-PCR and Western blot 
      method respectively, and then the relationship between Stat3 and Cyclin D1 
      protein expression level and relevant clinical factors of LSCC was explored. 
      RESULT: Compared to the normal larynx mucosa group, the expression level of Stat3 
      and Cyclin D1 was significantly higher in LSCC (P < 0.01). The high expression 
      level of Stat3 and Cyclin D1 protein in LSCC was correlated with the clinical 
      stage, tumor differentiation and lymph node metastases (P < 0.01). The expression 
      level of Stat3 was positively correlated with that of Cyclin D1, The correlation 
      coefficient(r) was 0.564 (P < 0.01) for the protein expression and 0.552 (P < 
      0.01) for the mRNA expression. CONCLUSION: Stat3 signaling pathway may play an 
      important role in the tumorigenesis and progression of LSCC. The expression level 
      of Stat3 and its target gene Cyclin D1 can reflect the malignancy degree of LSCC.
FAU - Wang, Lingu
AU  - Wang L
AD  - Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, 
      Medical College of Xi' an Jiaotong University, Xi' an710061, China.
FAU - Duan, Xinhu
AU  - Duan X
FAU - Tang, Xiabin
AU  - Tang X
FAU - Shao, Yuan
AU  - Shao Y
FAU - Zhao, Ruimin
AU  - Zhao R
FAU - Qian, Xiaoyun
AU  - Qian X
FAU - Gao, Xia
AU  - Gao X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CCND1 protein, human)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Cyclin D1/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - STAT3 Transcription Factor/genetics/*metabolism
EDAT- 2012/01/21 06:00
MHDA- 2012/06/09 06:00
CRDT- 2012/01/21 06:00
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Nov;25(21):966-9.