PMID- 22260079
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20171116
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 21
DP  - 2011 Nov
TI  - [Mutation of ING1 gene in laryngeal squamous cell carcinoma and its association 
      with p33ING1b protein expression].
PG  - 986-9
AB  - OBJECTIVE: To investigate the ING1 gene mutation status in human laryngeal 
      squamous cell carcinoma(LSCC), and the association of p33(ING1b) protein 
      expression with p53 protein expression. METHOD: DNA of LSCC tissue was extracted, 
      and nucleotide of the second exon was amplified and sequenced to determine the 
      chromosome status. The p23(ING1b) and p53 protein expression were detected by 
      immunohistochemistry and the association between them were analyzed. RESULT: No 
      mutation was detected in ING1 gene, but a single polymorphism from GGG to AGG at 
      codon 170 of ING1 gene was found in 2 of the 25 LSCC tissues. The 
      immunohistochemical analysis showed that 4 had positive p33(ING1b) expression. No 
      association was found between p33(ING1b) expression and LSCC clinical features, 
      or between p53 and clinical features. However, significant difference was found 
      between p33(ING1b) and p53 expression. p33(ING1b) tended to be negative in p53 
      expression positive tissue. CONCLUSION: ING1 gene mutation appears rare in LSCC. 
      In normal physical condition, p33(ING1b) may play a synergistic effect with p53 
      protein.
FAU - Li, Fengying
AU  - Li F
AD  - Clinical Laboratory, Affiliated Sir Run Run Shaw Hospital, Medical College of 
      Zhejiang University, Hangzhou 310016, China.
FAU - Li, Jun
AU  - Li J
FAU - Sheng, Hongqiang
AU  - Sheng H
FAU - Dai, Libo
AU  - Dai L
FAU - Cheng, Kejia
AU  - Cheng K
FAU - Lin, Shan
AU  - Lin S
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (ING1 protein, human)
RN  - 0 (Inhibitor of Growth Protein 1)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Female
MH  - Genes, Regulator
MH  - Humans
MH  - Inhibitor of Growth Protein 1
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Nuclear Proteins/*genetics
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Tumor Suppressor Proteins/*genetics
EDAT- 2012/01/21 06:00
MHDA- 2012/06/09 06:00
CRDT- 2012/01/21 06:00
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Nov;25(21):986-9.