PMID- 22260697
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20161125
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 40
IP  - 1
DP  - 2012 Feb
TI  - MKP-2: out of the DUSP-bin and back into the limelight.
PG  - 235-9
LID - 10.1042/BST20110648 [doi]
AB  - The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least 
      ten DUSPs (dual-specificity phosphatases) which function to terminate the 
      activity of the MAPKs (mitogen-activated protein kinases). Several members have 
      already been demonstrated to have distinct roles in immune function, cancer, 
      fetal development and metabolic disorders. One DUSP of renewed interest is the 
      inducible nuclear phosphatase MKP-2, which dephosphorylates both ERK 
      (extracellular-signal-regulated kinase) and JNK (c-Jun N-terminal kinase) in 
      vitro. Recently, the understanding of MKP-2 function has been advanced due to the 
      development of mouse knockout models, which has resulted in the discovery of 
      novel roles for MKP-2 in the regulation of sepsis, infection and cell-cycle 
      progression that are distinct from those of other DUSPs. However, many functions 
      for MKP-2 still await to be characterized.
FAU - Lawan, Ahmed
AU  - Lawan A
AD  - Division of Cell Biology, University of Strathclyde, Strathclyde Institute of 
      Pharmacy and Biomedical Sciences, 161 Cathedral Street, Glasgow G4 0RE, UK.
FAU - Torrance, Emma
AU  - Torrance E
FAU - Al-Harthi, Sameer
AU  - Al-Harthi S
FAU - Shweash, Muhannad
AU  - Shweash M
FAU - Alnasser, Sulaiman
AU  - Alnasser S
FAU - Neamatallah, Thikryat
AU  - Neamatallah T
FAU - Schroeder, Juliane
AU  - Schroeder J
FAU - Plevin, Robin
AU  - Plevin R
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Isoenzymes)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.1.3.16 (Mitogen-Activated Protein Kinase Phosphatases)
RN  - EC 3.1.3.48 (DUSP4 protein, human)
RN  - EC 3.1.3.48 (Dual-Specificity Phosphatases)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/enzymology
MH  - Cytoplasm/enzymology
MH  - Dual-Specificity Phosphatases/*metabolism
MH  - Humans
MH  - Isoenzymes/metabolism
MH  - Mitogen-Activated Protein Kinase Phosphatases/*metabolism
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Protein Processing, Post-Translational
EDAT- 2012/01/21 06:00
MHDA- 2012/05/19 06:00
CRDT- 2012/01/21 06:00
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - BST20110648 [pii]
AID - 10.1042/BST20110648 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2012 Feb;40(1):235-9. doi: 10.1042/BST20110648.