PMID- 22260700
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20220129
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 40
IP  - 1
DP  - 2012 Feb
TI  - ERK5 and its role in tumour development.
PG  - 251-6
LID - 10.1042/BST20110663 [doi]
AB  - The MEK5 [MAPK (mitogen-activated protein kinase)/ERK 
      (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well 
      studied MAPK signalling module. It has been proposed to play a role in the 
      pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 
      pathway using the 'hallmarks of cancer' as a framework and consider how this 
      pathway is deregulated. As well as playing a key role in endothelial cell 
      survival and tubular morphogenesis during tumour neovascularization, ERK5 is also 
      emerging as a regulator of tumour cell invasion and migration. Several oncogenes 
      can stimulate ERK5 activity, and protein levels are increased by a novel 
      amplification at chromosome locus 17p11 and by down-regulation of the microRNAs 
      miR-143 and miR-145. Together, these finding underscore the case for further 
      investigation into understanding the role of ERK5 in cancer.
FAU - Lochhead, Pamela A
AU  - Lochhead PA
AD  - Laboratory of Signalling and Cell Fate, The Babraham Institute, Babraham Research 
      Campus, Cambridge CB22 3AT, UK. pamela.lochhead@babraham.ac.uk
FAU - Gilley, Rebecca
AU  - Gilley R
FAU - Cook, Simon J
AU  - Cook SJ
LA  - eng
GR  - 09-0257/AICR_/Worldwide Cancer Research/United Kingdom
GR  - BB/C509190/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - BBS/E/B/0000H242/BB_/Biotechnology and Biological Sciences Research 
      Council/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 7)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 5)
RN  - EC 2.7.12.2 (MAP2K5 protein, human)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Enzyme Activation
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MAP Kinase Kinase 5/metabolism
MH  - MAP Kinase Signaling System
MH  - Mitogen-Activated Protein Kinase 7/genetics/*metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Neoplasms/blood supply/*enzymology/pathology
MH  - Neovascularization, Pathologic/enzymology
EDAT- 2012/01/21 06:00
MHDA- 2012/05/19 06:00
CRDT- 2012/01/21 06:00
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - BST20110663 [pii]
AID - 10.1042/BST20110663 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2012 Feb;40(1):251-6. doi: 10.1042/BST20110663.