PMID- 22260730
OWN - NLM
STAT- MEDLINE
DCOM- 20120713
LR  - 20211021
IS  - 1471-2164 (Electronic)
IS  - 1471-2164 (Linking)
VI  - 13
DP  - 2012 Jan 19
TI  - Transcriptional ontogeny of the developing liver.
PG  - 33
LID - 10.1186/1471-2164-13-33 [doi]
AB  - BACKGROUND: During embryogenesis the liver is derived from endodermal cells 
      lining the digestive tract. These endodermal progenitor cells contribute to 
      forming the parenchyma of a number of organs including the liver and pancreas. 
      Early in organogenesis the fetal liver is populated by hematopoietic stem cells, 
      the source for a number of blood cells including nucleated erythrocytes. A 
      comprehensive analysis of the transcriptional changes that occur during the early 
      stages of development to adulthood in the liver was carried out. RESULTS: We 
      characterized gene expression changes in the developing mouse liver at 
      gestational days (GD) 11.5, 12.5, 13.5, 14.5, 16.5, and 19 and in the neonate 
      (postnatal day (PND) 7 and 32) compared to that in the adult liver (PND67) using 
      full-genome microarrays. The fetal liver, and to a lesser extent the neonatal 
      liver, exhibited dramatic differences in gene expression compared to adults. 
      Canonical pathway analysis of the fetal liver signature demonstrated increases in 
      functions important in cell replication and DNA fidelity whereas most metabolic 
      pathways of intermediary metabolism were under expressed. Comparison of the 
      dataset to a number of previously published microarray datasets revealed 1) a 
      striking similarity between the fetal liver and that of the pancreas in both mice 
      and humans, 2) a nucleated erythrocyte signature in the fetus and 3) under 
      expression of most xenobiotic metabolism genes throughout development, with the 
      exception of a number of transporters associated with either hematopoietic cells 
      or cell proliferation in hepatocytes. CONCLUSIONS: Overall, these findings reveal 
      the complexity of gene expression changes during liver development and 
      maturation, and provide a foundation to predict responses to chemical and drug 
      exposure as a function of early life-stages.
FAU - Lee, Janice S
AU  - Lee JS
AD  - National Health and Environmental Effects Research Laboratory, United States 
      Environmental Protection Agency, Research Triangle Park, NC 27711, USA. 
      lee.janices@epa.gov
FAU - Ward, William O
AU  - Ward WO
FAU - Knapp, Geremy
AU  - Knapp G
FAU - Ren, Hongzu
AU  - Ren H
FAU - Vallanat, Beena
AU  - Vallanat B
FAU - Abbott, Barbara
AU  - Abbott B
FAU - Ho, Karen
AU  - Ho K
FAU - Karp, Seth J
AU  - Karp SJ
FAU - Corton, J Christopher
AU  - Corton JC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120119
PL  - England
TA  - BMC Genomics
JT  - BMC genomics
JID - 100965258
RN  - 0 (Makorin ring finger protein 1)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (Xenobiotics)
RN  - 139076-35-0 (Polypyrimidine Tract-Binding Protein)
SB  - IM
MH  - Animals
MH  - Cluster Analysis
MH  - Erythroid Cells/metabolism
MH  - Female
MH  - Fetus
MH  - *Gene Expression Profiling
MH  - *Gene Expression Regulation, Developmental
MH  - Hematopoietic Stem Cells/metabolism
MH  - Humans
MH  - Liver/*growth & development/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Tissue Proteins/genetics
MH  - Organ Specificity/genetics
MH  - Pancreas/growth & development/metabolism
MH  - Polypyrimidine Tract-Binding Protein/genetics
MH  - Pregnancy
MH  - Ribonucleoproteins/genetics
MH  - *Transcription, Genetic
MH  - Wnt Signaling Pathway
MH  - Xenobiotics/metabolism
PMC - PMC3306746
EDAT- 2012/01/21 06:00
MHDA- 2012/07/14 06:00
PMCR- 2012/01/19
CRDT- 2012/01/21 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2012/01/19 00:00 [accepted]
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2012/07/14 06:00 [medline]
PHST- 2012/01/19 00:00 [pmc-release]
AID - 1471-2164-13-33 [pii]
AID - 10.1186/1471-2164-13-33 [doi]
PST - epublish
SO  - BMC Genomics. 2012 Jan 19;13:33. doi: 10.1186/1471-2164-13-33.