PMID- 22261688
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20161125
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 167
IP  - 2
DP  - 2013 Jul 31
TI  - Right ventricular long-axis response to different chronic loading conditions: its 
      relevance to clinical symptoms.
PG  - 378-82
LID - S0167-5273(11)02267-4 [pii]
LID - 10.1016/j.ijcard.2011.12.086 [doi]
AB  - BACKGROUND: The intervention timing in atrial septal defect (ASD) or pulmonary 
      valvular stenosis (PVS) is more dependent on symptoms than right ventricular (RV) 
      damage in clinical practice. RV long-axis function is sensitive in revealing RV 
      myocardial dysfunction. We evaluate the impact of different chronic loading 
      conditions on RV long-axis function and its relationship to patients' symptoms in 
      ASD or PVS. METHODS: Transthoracic echocardiography was performed in normals 
      (n=39) and patients with isolated secundum ASD (n=45) or PVS (n=38). RV volume- 
      and pressure-overloading were defined as the ratio of RV/left ventricular 
      end-diastolic dimension >/= 0.5 and RV systolic pressure >/= 40 mmHg, respectively. 
      RV long-axis dysfunction was defined as M-mode tricuspid annular plane systolic 
      excursion (TAPSE) <1.6 cm. New York Heart Association (NYHA) functional class and 
      other symptoms (decreased exercise tolerance, palpitation and chest pain) were 
      recorded. RESULTS: Thirty-nine (32.0%) had normal loading (Group 1; 39 normals); 
      24 (19.6%) had isolated volume-overloading (Group 2; all ASDs); 21 (17.2%) had 
      isolated pressure-overloading (Group 3; 21 PVSs) and 38 (31.1%) had both 
      overloading conditions (Group 4; 21 ASDs and 17 PVSs). RV long-axis dysfunction 
      in abnormal loading groups were zero (0%, Group 2), 21 (100%, Group 3) and 22 
      (57.8%, Group 4) (chi(2)=45.9, p<0.001). Group 3 were more symptomatic (NYHA 
      functional class 2.5 +/- 0.6 versus 1.6 +/- 0.5, p<0.05) and had lower TAPSE (1.6 +/- 
      0.4 versus 3.0 +/- 0.7 cm, p<0.05) than Group 2. RV long-axis dysfunction was the 
      strongest predictor of the presence of symptoms (odds ratio=9.298, p<0.001). 
      CONCLUSION: Chronic volume-overloading accentuates while pressure-overloading 
      attenuates RV long-axis excursion and its impairment was associated with the 
      presence of symptoms.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Fang, Fang
AU  - Fang F
AD  - Institute of Vascular Medicine and Division of Cardiology, Li Ka Shing Institute 
      of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong 
      Kong, Shatin, Hong Kong, China.
FAU - Henein, Micheal Y
AU  - Henein MY
FAU - Yu, Cheuk-Man
AU  - Yu CM
FAU - Li, Wei
AU  - Li W
FAU - Kaya, Mehmet G
AU  - Kaya MG
FAU - Coats, Andrew J
AU  - Coats AJ
FAU - Lam, Yat-Yin
AU  - Lam YY
LA  - eng
PT  - Journal Article
DEP - 20120120
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2013 Jul 1;166(3):739-40. PMID: 23046600
MH  - Adolescent
MH  - Adult
MH  - Echocardiography/methods
MH  - Exercise Tolerance/physiology
MH  - Female
MH  - Heart Function Tests/*methods
MH  - Heart Septal Defects, Atrial/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/*physiology
MH  - Time Factors
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/physiopathology
MH  - Ventricular Function, Right/*physiology
MH  - Young Adult
EDAT- 2012/01/21 06:00
MHDA- 2014/02/25 06:00
CRDT- 2012/01/21 06:00
PHST- 2011/10/18 00:00 [received]
PHST- 2011/12/06 00:00 [revised]
PHST- 2011/12/25 00:00 [accepted]
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - S0167-5273(11)02267-4 [pii]
AID - 10.1016/j.ijcard.2011.12.086 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Jul 31;167(2):378-82. doi: 10.1016/j.ijcard.2011.12.086. Epub 
      2012 Jan 20.