PMID- 22262478
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20161125
IS  - 1522-1466 (Electronic)
IS  - 1522-1466 (Linking)
VI  - 302
IP  - 9
DP  - 2012 May 1
TI  - Cytokine elevation and transaminitis after laparoscopic donor nephrectomy.
PG  - F1104-11
LID - 10.1152/ajprenal.00543.2011 [doi]
AB  - Acute kidney injury frequently occurs in the critically ill and often progresses 
      into multiorgan dysfunction syndrome, resulting in high mortality. We previously 
      showed that nephrectomized mice had increased interleukin (IL)-6 and tumor 
      necrosis factor (TNF)-alpha that directly contributed to systemic inflammation and 
      hepatic injury. In this study, we examined whether patients undergoing 
      laparoscopic donor nephrectomy have increased postoperative cytokine levels with 
      injury to the liver and whether the remaining kidney sustains injury. Serial 
      serum and urine samples were collected from 32 patients undergoing laparoscopic 
      donor nephrectomy and 17 patients undergoing nonrenal laparoscopic surgery. Serum 
      IL-6, IL-18, TNF-alpha and monocyte chemotactic protein-1 (MCP-1) (markers of 
      systemic inflammation) and urinary neutrophil gelatinase-associated lipocalin 
      (NGAL), kidney injury molecule-1 (KIM-1), MCP-1, and IL-18 (markers of acute 
      kidney injury) were quantified by enzyme-linked immunosorbent assay. We also 
      analyzed serum creatinine, aspartate transaminase (AST), and alanine transaminase 
      to assess liver injury. Patients who underwent donor nephrectomy not only 
      demonstrated increased serum creatinine but also had significant increases in 
      serum IL-6, MCP-1, and AST. Serum TNF-alpha also trended upward in donor nephrectomy 
      patients. Finally, the donor nephrectomy group showed increased urinary NGAL but 
      not KIM-1 at 24 h. Taken together, our findings of increased serum IL-6, MCP-1, 
      and AST after donor nephrectomy suggest that an acute reduction of kidney 
      function induces systemic inflammation and may have distant effects on the liver. 
      Further studies are needed to correlate increased urinary NGAL after donor 
      nephrectomy both as a potential marker for renal tubular stress and/or 
      hypertrophy in the contralateral kidney.
FAU - Yap, Steven
AU  - Yap S
AD  - Department of Anesthesiology, College of Physicians and Surgeons of Columbia 
      University, New York, NY 10032-3784, USA.
FAU - Park, Sang Won
AU  - Park SW
FAU - Egan, Brian
AU  - Egan B
FAU - Lee, H Thomas
AU  - Lee HT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120118
PL  - United States
TA  - Am J Physiol Renal Physiol
JT  - American journal of physiology. Renal physiology
JID - 100901990
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Virus)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
SB  - IM
MH  - Acute Kidney Injury/blood/epidemiology/urine
MH  - Acute-Phase Proteins
MH  - Adult
MH  - Aspartate Aminotransferases/*blood
MH  - Biomarkers/blood/urine
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Creatinine/blood
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Humans
MH  - Interleukin-18/*blood/urine
MH  - Interleukin-6/*blood/urine
MH  - Kidney Transplantation
MH  - *Laparoscopy
MH  - Lipocalin-2
MH  - Lipocalins/blood
MH  - Liver Diseases/blood/epidemiology/urine
MH  - *Living Donors
MH  - Male
MH  - Membrane Glycoproteins/blood
MH  - Middle Aged
MH  - *Nephrectomy
MH  - Postoperative Period
MH  - Proto-Oncogene Proteins/blood
MH  - Receptors, Virus/blood
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*blood/urine
EDAT- 2012/01/21 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/01/21 06:00
PHST- 2012/01/21 06:00 [entrez]
PHST- 2012/01/21 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - ajprenal.00543.2011 [pii]
AID - 10.1152/ajprenal.00543.2011 [doi]
PST - ppublish
SO  - Am J Physiol Renal Physiol. 2012 May 1;302(9):F1104-11. doi: 
      10.1152/ajprenal.00543.2011. Epub 2012 Jan 18.