PMID- 22266520
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 2
DP  - 2012 Feb 29
TI  - Effect of spectrum bias on the diagnostic accuracy of spectral-domain optical 
      coherence tomography in glaucoma.
PG  - 1058-65
LID - 10.1167/iovs.11-8463 [doi]
AB  - PURPOSE: To evaluate the influence of a control group on the diagnostic accuracy 
      of spectral-domain optical coherence tomography (SD-OCT) in early glaucoma. 
      METHODS: In a diagnostic, case-control study, 119 eyes of 60 normal subjects with 
      no findings suspicious for glaucoma (control cohort 1); 76 eyes of 41 subjects 
      referred by general ophthalmologists as glaucoma suspects based on optic disc 
      morphology, but found by glaucoma experts to be normal but with physiological 
      variations in their optic nerves (control cohort 2); and 65 eyes of 46 
      early-glaucoma patients (cases) underwent imaging of the optic nerve head (ONH), 
      retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) by SD-OCT. 
      RESULTS: Areas under the receiver operating characteristic curves (AUC) of ONH 
      parameters discriminating glaucomatous eyes from normal eyes of control cohort 2 
      were significantly lesser (P < 0.001) than those discriminating glaucomatous eyes 
      from normal eyes of control cohort 1. AUCs of RNFL parameters discriminating 
      glaucomatous eyes from normal eyes of control cohorts 2 and 1 were comparable. 
      Although the AUCs of GCC thickness parameters were comparable, AUCs of GCC focal 
      and global loss volume in control cohort 2 (0.684 and 0.671. respectively) were 
      significantly less (P < 0.05) than in control cohort 1 (0.881 and 0.841, 
      respectively). CONCLUSIONS: The effectiveness of most SD-OCT parameters in 
      detecting glaucoma significantly decreased when evaluated against a clinically 
      relevant control group with suspicious-looking optic nerves compared with that 
      against a control group consisting of normal subjects with no findings suspicious 
      for glaucoma.
FAU - Rao, Harsha L
AU  - Rao HL
AD  - VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India. 
      harshabl.76@gmail.com
FAU - Kumbar, Tukaram
AU  - Kumbar T
FAU - Addepalli, Uday K
AU  - Addepalli UK
FAU - Bharti, Neha
AU  - Bharti N
FAU - Senthil, Sirisha
AU  - Senthil S
FAU - Choudhari, Nikhil S
AU  - Choudhari NS
FAU - Garudadri, Chandra S
AU  - Garudadri CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120229
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Area Under Curve
MH  - Axons/*pathology
MH  - Bias
MH  - Case-Control Studies
MH  - Control Groups
MH  - Early Diagnosis
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Gonioscopy
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Ocular Hypertension/diagnosis
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
MH  - Tonometry, Ocular
EDAT- 2012/01/24 06:00
MHDA- 2012/04/20 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - iovs.11-8463 [pii]
AID - 10.1167/iovs.11-8463 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Feb 29;53(2):1058-65. doi: 10.1167/iovs.11-8463.