PMID- 22266524
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20130109
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 3
DP  - 2012 Mar 9
TI  - Analysis of progression of reticular pseudodrusen by spectral domain-optical 
      coherence tomography.
PG  - 1264-70
LID - 10.1167/iovs.11-9063 [doi]
AB  - PURPOSE: To analyze reticular pseudodrusen progression using spectral 
      domain-optical coherence tomography (SD-OCT). METHODS: Thirty-three consecutive 
      patients (48 eyes) underwent SD-OCT using the eye-tracked follow-up protocol 24 +/- 
      2 months after baseline examination. Each pair of B-scans (only one per eye was 
      evaluated among those showing pseudodrusen progression) was compared with respect 
      to pseudodrusen appearance and retinal layer structure. Stage 1 pseudodrusen was 
      defined as granular material between the RPE and the inner segment/outer segment 
      (IS/OS), stage 2 as mounds of material sufficient to alter the contour of the 
      IS/OS, stage 3 as thicker material adopting a conical appearance and breaking 
      through the IS/OS, and stage 4 as fading of the material because of reabsorption 
      and migration within the inner retinal layers. RESULTS: A total of 78 
      pseudodrusen (detected on the 48 analyzed B-scans, and counting for a mean of 2.3 
      pseudodrusen per scan) showed progression over a mean of 23.9 +/- 1.2 months. All 
      58 pseudodrusen (100%) graded as stage 1 at baseline examination progressed to 
      stage 2. Thirteen of 16 pseudodrusen (81.3%) graded as stage 2 at baseline 
      examination progressed to stage 3, and three (18.7%) progressed to stage 4. All 
      four pseudodrusen (100%) graded as stage 3 at baseline examination progressed to 
      stage 4. Among pseudodrusen that were stage 3 or 4 at follow-up (n = 20), 100% 
      had IS/OS disruption whereas 12.1% (n = 7) had IS/OS disruption at stage 1 or 2 
      (n = 58) (OR, 1.736; 95% CI, 1.02-2.43). CONCLUSIONS: The frequency of stage 
      changes over time suggest that reticular pseudodrusen are dynamic pathologic 
      structures.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil 
      University Paris Est Creteil, Creteil, France. giuseppe.querques@hotmail.it
FAU - Canoui-Poitrine, Florence
AU  - Canoui-Poitrine F
FAU - Coscas, Florence
AU  - Coscas F
FAU - Massamba, Nathalie
AU  - Massamba N
FAU - Querques, Lea
AU  - Querques L
FAU - Mimoun, Gerard
AU  - Mimoun G
FAU - Bandello, Francesco
AU  - Bandello F
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120309
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Prognosis
MH  - Retinal Drusen/*diagnosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tomography, Optical Coherence/*methods
EDAT- 2012/01/24 06:00
MHDA- 2012/05/09 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - iovs.11-9063 [pii]
AID - 10.1167/iovs.11-9063 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Mar 9;53(3):1264-70. doi: 10.1167/iovs.11-9063.