PMID- 22267491
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211021
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 146
IP  - 5
DP  - 2012 May
TI  - Human papillomavirus outcomes in an access-to-care laryngeal cancer cohort.
PG  - 730-8
LID - 10.1177/0194599811434482 [doi]
AB  - OBJECTIVE: Human papillomavirus (HPV), particularly HPV16, is a causative agent 
      for 25% of head and neck squamous cell cancer, including laryngeal squamous cell 
      cancer (LSCC). HPV-positive (HPV+ve) patients, particularly those with 
      oropharyngeal SCC, have improved prognosis. For LSCC patients, this remains to be 
      established. The goal was to determine stage and survival outcomes in LSCC in the 
      context of HPV infection. STUDY DESIGN: Historical cohort study. SETTING: Primary 
      care academic health system. SUBJECTS AND METHODS: In 79 patients with primary 
      LSCC, HPV was determined using real-time quantitative polymerase chain reaction. 
      chi(2) or Fisher exact test was used to test the association of HPV+ve with 21 risk 
      factors including race, stage, gender, age, smoking, alcohol, treatment, and 
      health insurance. Kaplan-Meier and log-rank tests were used to study the 
      association of HPV and LSCC survival outcome. RESULTS: HPV16 was detected in 27% 
      of LSCC patients. Caucasian American (CA) patients had higher HPV prevalence 
      (33%) than did African American (AA) LSCC patients (16%; P = .058). HPV was 
      significantly associated with gender (P = .016) and insurance type (P = .001). 
      There were no differences in survival between HPV+ve and HPV-negative (HPV-ve) 
      patients. There was no association with HPV and other risk factors including 
      stage (early vs late). CONCLUSION: We found a high prevalence of HPV in men and a 
      lower prevalence of HPV infection in AA compared with CA. Despite the strikingly 
      better survival of patients with HPV+ve oropharyngeal tumors, even when adjusted 
      for smoking, this correlation does not seem to hold true in the larynx. Larger 
      multiethnic LSCC cohorts are needed to more clearly delineate HPV-related 
      survival across ethnicities.
FAU - Stephen, Josena K
AU  - Stephen JK
AD  - Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, 
      Michigan 48202, USA. jstephe2@hfhs.org
FAU - Chen, Kang Mei
AU  - Chen KM
FAU - Shah, Veena
AU  - Shah V
FAU - Havard, Shaleta
AU  - Havard S
FAU - Lu, Mei
AU  - Lu M
FAU - Schweitzer, Vanessa P
AU  - Schweitzer VP
FAU - Gardner, Glendon
AU  - Gardner G
FAU - Worsham, Maria J
AU  - Worsham MJ
LA  - eng
GR  - R01 DE015990/DE/NIDCR NIH HHS/United States
GR  - R01 DE 15990/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120120
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*virology
MH  - Chi-Square Distribution
MH  - Female
MH  - Human papillomavirus 16/*isolation & purification
MH  - Humans
MH  - Laryngeal Neoplasms/*virology
MH  - Male
MH  - Michigan/epidemiology
MH  - Middle Aged
MH  - Papillomavirus Infections/*complications/epidemiology/ethnology
MH  - Prevalence
MH  - Prognosis
MH  - Real-Time Polymerase Chain Reaction
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Survival Rate
PMC - PMC3728652
MID - NIHMS486658
EDAT- 2012/01/24 06:00
MHDA- 2012/07/20 06:00
PMCR- 2013/07/31
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
PHST- 2013/07/31 00:00 [pmc-release]
AID - 0194599811434482 [pii]
AID - 10.1177/0194599811434482 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2012 May;146(5):730-8. doi: 10.1177/0194599811434482. 
      Epub 2012 Jan 20.