PMID- 22267540
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20211021
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Print)
IS  - 1933-7191 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Jun
TI  - Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.
PG  - 572-9
LID - 10.1177/1933719111430998 [doi]
AB  - Statins are potent inhibitors of the endogenous mevalonate pathway. Besides 
      inhibiting cholesterol biosynthesis, statins may also demonstrate 
      anti-inflammatory properties. Inflammation is implicated in the attachment and 
      invasion of endometrial cells to the peritoneal surface and growth of ectopic 
      endometrium by inducing proliferation and angiogenesis. In this study, the effect 
      of statins on monocyte chemotactic protein 1 (MCP-1) expression in endometriotic 
      implants in nude mouse model and in cultured endometriotic cells was evaluated. 
      In mouse model, simvastatin decreased MCP-1 expression in a dose-dependent manner 
      in endometriotic implants (P < .05). Similarly, both simvastatin and mevastatin 
      revealed a dose-dependent inhibition of MCP-1 production in cultured 
      endometriotic cells (P < .01). This inhibitory effect of the statins on MCP-1 
      production was reversed by the downstream substrates of the mevalonate pathway. 
      Moreover, statins decreased MCP-1 messenger RNA expression in cultured 
      endometriotic cells (P < .05). In conclusion, statins exert anti-inflammatory 
      effect in endometriotic cells and could provide a potential treatment of 
      endometriosis in the future.
FAU - Cakmak, Hakan
AU  - Cakmak H
AD  - Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University 
      School of Medicine, New Haven, CT 06520, USA.
FAU - Basar, Murat
AU  - Basar M
FAU - Seval-Celik, Yasemin
AU  - Seval-Celik Y
FAU - Osteen, Kevin G
AU  - Osteen KG
FAU - Duleba, Antoni J
AU  - Duleba AJ
FAU - Taylor, Hugh S
AU  - Taylor HS
FAU - Lockwood, Charles J
AU  - Lockwood CJ
FAU - Arici, Aydin
AU  - Arici A
LA  - eng
GR  - R01 HD055648/HD/NICHD NIH HHS/United States
GR  - U54 HD052668/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120119
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Chemokine CCL2)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Cells, Cultured
MH  - Chemokine CCL2/analysis/*antagonists & inhibitors/genetics
MH  - Disease Models, Animal
MH  - Endometriosis/*metabolism
MH  - Endometrium/transplantation
MH  - Female
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Mice
MH  - Mice, Nude
MH  - Middle Aged
MH  - RNA, Messenger/analysis
MH  - Simvastatin/pharmacology
MH  - Transplantation, Heterologous
PMC - PMC3439122
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2012/01/24 06:00
MHDA- 2012/10/23 06:00
PMCR- 2013/06/01
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 1933719111430998 [pii]
AID - 10.1177_1933719111430998 [pii]
AID - 10.1177/1933719111430998 [doi]
PST - ppublish
SO  - Reprod Sci. 2012 Jun;19(6):572-9. doi: 10.1177/1933719111430998. Epub 2012 Jan 
      19.