PMID- 22268134
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20211021
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 185
IP  - 7
DP  - 2012 Apr 1
TI  - Interstitial lung abnormalities and reduced exercise capacity.
PG  - 756-62
LID - 10.1164/rccm.201109-1618OC [doi]
AB  - RATIONALE: The relationship between interstitial lung abnormalities (ILA) and 
      exercise capacity has not been comprehensively evaluated. OBJECTIVES: To assess 
      the validity of the 6-minute walk test in subjects with ILA, and to examine the 
      association between ILA and 6-minute walk distance (6MWD). METHODS: Spearman 
      correlation coefficients were used to assess the strength of the relationships 
      between 6MWD and relevant measures of dyspnea, health-related quality of life, 
      and pulmonary function in a cohort of 2,416 people who smoke from the COPDGene 
      study. Unadjusted and adjusted linear and logistic regression models were used to 
      assess the strength of the association between ILA and 6MWD. MEASUREMENTS AND 
      MAIN RESULTS: In all subjects, and in those with ILA, 6MWD in COPDGene was 
      associated with relevant clinical and physiologic measures. The mean 6MWD in 
      COPDGene subjects with ILA was 386 m (SD, 128 m), and 82% and 19% of subjects 
      with ILA had 6MWDs less than or equal to 500 and 250 m, respectively. ILA was 
      associated with a reduced 6MWD in univariate (-30 m; 95% confidence interval, -50 
      to -10; P = 0.004) and multivariate models (-19 m; 95% confidence interval, -33 
      to -5; P = 0.008). Compared with subjects without ILA, subjects with ILA had an 
      80% and 77% increase in their odds to have a walk distance limited to less than 
      or equal to 500 and 250 m, respectively. Although these findings were dependent 
      on ILA subtype, they were not limited to those with COPD. CONCLUSIONS: Our study 
      demonstrates that ILA is associated with measurable decrements in the 6MWD of 
      people who smoke. Clinical trial registered with www.clinicaltrials.gov (NCT 
      00608764).
FAU - Doyle, Tracy J
AU  - Doyle TJ
AD  - Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, MA 
      02115, USA.
FAU - Washko, George R
AU  - Washko GR
FAU - Fernandez, Isis E
AU  - Fernandez IE
FAU - Nishino, Mizuki
AU  - Nishino M
FAU - Okajima, Yuka
AU  - Okajima Y
FAU - Yamashiro, Tsuneo
AU  - Yamashiro T
FAU - Divo, Miguel J
AU  - Divo MJ
FAU - Celli, Bartolome R
AU  - Celli BR
FAU - Sciurba, Frank C
AU  - Sciurba FC
FAU - Silverman, Edwin K
AU  - Silverman EK
FAU - Hatabu, Hiroto
AU  - Hatabu H
FAU - Rosas, Ivan O
AU  - Rosas IO
FAU - Hunninghake, Gary M
AU  - Hunninghake GM
CN  - COPDGene Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00608764
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - T32 HL007633/HL/NHLBI NIH HHS/United States
GR  - UL1 RR024153/RR/NCRR NIH HHS/United States
GR  - 5T32 HL007633-25/HL/NHLBI NIH HHS/United States
GR  - U01 HL089897/HL/NHLBI NIH HHS/United States
GR  - R21CA116271-2/CA/NCI NIH HHS/United States
GR  - K08 HL092222/HL/NHLBI NIH HHS/United States
GR  - K23 HL087030/HL/NHLBI NIH HHS/United States
GR  - R21 CA116271/CA/NCI NIH HHS/United States
GR  - K23 HL089353/HL/NHLBI NIH HHS/United States
GR  - K23 CA157631/CA/NCI NIH HHS/United States
GR  - R01 HL111024/HL/NHLBI NIH HHS/United States
GR  - U01 HL089856/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120120
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
SB  - IM
CIN - Am J Respir Crit Care Med. 2012 Apr 1;185(7):697-9. PMID: 22467803
MH  - Aged
MH  - Exercise Test
MH  - *Exercise Tolerance/physiology
MH  - Female
MH  - Humans
MH  - Lung Diseases, Interstitial/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/physiopathology
MH  - Smoking/adverse effects/physiopathology
MH  - Walking/physiology
PMC - PMC3326424
EDAT- 2012/01/24 06:00
MHDA- 2012/05/17 06:00
PMCR- 2013/04/01
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - rccm.201109-1618OC [pii]
AID - 201109-1618OC [pii]
AID - 10.1164/rccm.201109-1618OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2012 Apr 1;185(7):756-62. doi: 
      10.1164/rccm.201109-1618OC. Epub 2012 Jan 20.