PMID- 22268374
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20220317
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - Renal amyloidosis in dogs: a retrospective study of 91 cases with comparison of 
      the disease between Shar-Pei and non-Shar-Pei dogs.
PG  - 259-68
LID - 10.1111/j.1939-1676.2011.00878.x [doi]
AB  - BACKGROUND: Renal amyloidosis (RA) is a progressive and fatal renal disease. 
      HYPOTHESIS: Clinical and pathologic manifestations of RA differ between Chinese 
      Shar-Pei (CSPs) and non-Shar-Pei (NSPs) dogs. ANIMALS: 91 client-owned dogs. 
      METHODS: Retrospective review of medical records of dogs with a histological 
      diagnosis of RA. Clinical and clinicopathologic data, hospitalization, 
      complications, and outcome were compared between CSPs and NSPs. RESULTS: Comorbid 
      diseases were present in 64% of all dogs. CSPs were significantly younger 
      compared to NSPs (median, 4.8 years; range: 3.6-17 versus median: 9.0 years; 
      range: 2.4-11.1; P < .0001). The frequency of hypoalbuminemia, the most common 
      biochemical abnormality, was higher in NSPs compared to CSPs (100% versus 64.7%, 
      respectively; P < .001). Median serum creatinine concentration at presentation 
      was 5.5 mg/dL, and was 3-fold higher in CSPs compared to NSPs (P = .005). 
      Increased urine protein : creatinine ratio was present in 96% of all dogs. 
      Nephrotic syndrome was present in 10% of NSPs but not in CSPs. Glomerular amyloid 
      deposition, present in both CSPs (78.6%) and NSPs (95.6%) was most commonly 
      diffuse, global, and severe. Renal medullar amyloidosis was more common in CSPs 
      (100%) compared to NSPs (49.0%, P = .002), as was extrarenal amyloid deposition. 
      The median survival time of all dogs was 5 days (range: 0-443 days). Serum 
      creatinine concentration was significantly and negatively associated with 
      survival (P = .025). CONCLUSIONS AND CLINICAL RELEVANCE: The clinical and 
      pathologic manifestations of amyloidosis differ between CSPs and NSPs. The 
      survival time observed herein was unexpectedly low, and argues for early 
      surveillance and management of the underlying predisposing conditions.
CI  - Copyright (c) 2012 by the American College of Veterinary Internal Medicine.
FAU - Segev, G
AU  - Segev G
AD  - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Jerusalem, 
      Israel. gsegev@agri.huji.ac.il
FAU - Cowgill, L D
AU  - Cowgill LD
FAU - Jessen, S
AU  - Jessen S
FAU - Berkowitz, A
AU  - Berkowitz A
FAU - Mohr, C F
AU  - Mohr CF
FAU - Aroch, I
AU  - Aroch I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120123
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Amyloidosis/blood/pathology/urine/*veterinary
MH  - Animals
MH  - Creatinine/blood/urine
MH  - Dog Diseases/blood/*pathology/urine
MH  - Dogs
MH  - Female
MH  - Histocytochemistry/veterinary
MH  - Hypoalbuminemia/blood/pathology/urine/veterinary
MH  - Kaplan-Meier Estimate
MH  - Kidney Diseases/blood/pathology/urine/*veterinary
MH  - Kidney Glomerulus/pathology
MH  - Male
MH  - Retrospective Studies
EDAT- 2012/01/25 06:00
MHDA- 2012/07/27 06:00
CRDT- 2012/01/25 06:00
PHST- 2011/07/31 00:00 [received]
PHST- 2011/10/24 00:00 [revised]
PHST- 2011/11/23 00:00 [accepted]
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - 10.1111/j.1939-1676.2011.00878.x [doi]
PST - ppublish
SO  - J Vet Intern Med. 2012 Mar-Apr;26(2):259-68. doi: 
      10.1111/j.1939-1676.2011.00878.x. Epub 2012 Jan 23.