PMID- 22270953
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20240513
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 12
IP  - 2
DP  - 2012 Jan 24
TI  - Targeting MET in cancer: rationale and progress.
PG  - 89-103
LID - 10.1038/nrc3205 [doi]
AB  - Uncontrolled cell survival, growth, angiogenesis and metastasis are essential 
      hallmarks of cancer. Genetic and biochemical data have demonstrated that the 
      growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and 
      its receptor, the tyrosine kinase MET, have a causal role in all of these 
      processes, thus providing a strong rationale for targeting these molecules in 
      cancer. Parallel progress in understanding the structure and function of HGF/SF, 
      MET and associated signalling components has led to the successful development of 
      blocking antibodies and a large number of small-molecule MET kinase inhibitors. 
      In this Review, we discuss these advances, as well as results from recent 
      clinical studies that demonstrate that inhibiting MET signalling in several types 
      of solid human tumours has major therapeutic value.
FAU - Gherardi, Ermanno
AU  - Gherardi E
AD  - Medical Research Council (MRC) Centre, Hills Road, Cambridge CB2 2QH, UK. 
      egherard@mrc-lmb.cam.ac.uk
FAU - Birchmeier, Walter
AU  - Birchmeier W
FAU - Birchmeier, Carmen
AU  - Birchmeier C
FAU - Vande Woude, George
AU  - Vande Woude G
LA  - eng
GR  - G0800025/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120124
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
EIN - Nat Rev Cancer. 2012 Sep;12(9):637
MH  - Epithelial-Mesenchymal Transition
MH  - Hepatocyte Growth Factor/metabolism/physiology
MH  - Humans
MH  - Neoplasms/*genetics/pathology
MH  - Proto-Oncogene Proteins c-met/*genetics/metabolism
MH  - Signal Transduction
EDAT- 2012/01/25 06:00
MHDA- 2012/03/07 06:00
CRDT- 2012/01/25 06:00
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - nrc3205 [pii]
AID - 10.1038/nrc3205 [doi]
PST - epublish
SO  - Nat Rev Cancer. 2012 Jan 24;12(2):89-103. doi: 10.1038/nrc3205.