PMID- 22272075
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20220606
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 12
IP  - 12
DP  - 2011
TI  - Inhibition of extracellular signal-regulated kinases ameliorates 
      hypertension-induced renal vascular remodeling in rat models.
PG  - 8333-46
LID - 10.3390/ijms12128333 [doi]
AB  - The aim of this study is to investigate the effect of the extracellular 
      signal-regulated kinases 1/2 (ERK1/2) inhibitor, PD98059, on high blood pressure 
      and related vascular changes. Blood pressure was recorded, thicknesses of renal 
      small artery walls were measured and ERK1/2 immunoreactivity and erk2 mRNA in 
      renal vascular smooth muscle cells (VSMCs) and endothelial cells were detected by 
      immunohistochemistry and in situ hybridization in normotensive wistar kyoto (WKY) 
      rats, spontaneously hypertensive rats (SHR) and PD98059-treated SHR. Compared 
      with normo-tensive WKY rats, SHR developed hypertension at 8 weeks of age, 
      thickened renal small artery wall and asymmetric arrangement of VSMCs at 16 and 
      24 weeks of age. Phospho-ERK1/2 immunoreactivity and erk2 mRNA expression levels 
      were increased in VSMCs and endothelial cells of the renal small arteries in the 
      SHR. Treating SHR with PD98059 reduced the spontaneous hypertension-induced 
      vascular wall thickening. This effect was associated with suppressions of erk2 
      mRNA expression and ERK1/2 phosphorylation in VSMCs and endothelial cells of the 
      renal small arteries. It is concluded that inhibition of ERK1/2 ameliorates 
      hypertension induced vascular remodeling in renal small arteries.
FAU - Jing, Li
AU  - Jing L
AD  - Department of Pathology, Basic Medical College, Ningxia Medical University, 
      Yinchuan 750004, Ningxia, China; Department of Pharmaceutical Sciences, 
      Biomanufacturing Research Institute and Technology Enterprise (BRITE), North 
      Carolina Central University, Durham, NC 27707, USA. ljing@nccu.edu
FAU - Zhang, Jianzhong
AU  - Zhang J
FAU - Sun, Jinping
AU  - Sun J
FAU - Guo, Fengying
AU  - Guo F
FAU - An, Xin
AU  - An X
FAU - Yang, Kan
AU  - Yang K
FAU - Li, Ping Andy
AU  - Li PA
LA  - eng
GR  - R01 DK075476/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111128
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Flavonoids)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - SJE1IO5E3I (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one)
SB  - IM
MH  - Animals
MH  - Endothelium, Vascular/metabolism
MH  - Female
MH  - Flavonoids/*pharmacology/therapeutic use
MH  - Hypertension/drug therapy/*metabolism/pathology
MH  - MAP Kinase Signaling System
MH  - Male
MH  - Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/genetics/*metabolism
MH  - Mitogen-Activated Protein Kinase 3/antagonists & inhibitors/genetics/*metabolism
MH  - Myocytes, Smooth Muscle/metabolism
MH  - Protein Kinase Inhibitors/*pharmacology/therapeutic use
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Renal Artery/drug effects/*metabolism/pathology
MH  - Vascular Remodeling/*drug effects
PMC - PMC3257072
OTO - NOTNLM
OT  - artery
OT  - extracellular signal-regulated kinase
OT  - hypertension
OT  - kidney SHR
OT  - vascular remodeling
EDAT- 2012/01/25 06:00
MHDA- 2012/01/25 06:01
PMCR- 2011/01/01
CRDT- 2012/01/25 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2011/09/19 00:00 [revised]
PHST- 2011/10/21 00:00 [accepted]
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/01/25 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - ijms12128333 [pii]
AID - ijms-12-08333 [pii]
AID - 10.3390/ijms12128333 [doi]
PST - ppublish
SO  - Int J Mol Sci. 2011;12(12):8333-46. doi: 10.3390/ijms12128333. Epub 2011 Nov 28.