PMID- 22272617
OWN - NLM
STAT- MEDLINE
DCOM- 20120907
LR  - 20220309
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 9
IP  - 4
DP  - 2012 May
TI  - Hippocampal BDNF expression in a tau transgenic mouse model.
PG  - 406-10
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder characterized by 
      extracellular accumulation of amyloid deposits and intracellular neurofibrillary 
      tangles (NFT) composed of hyperphosphorylated Tau proteins. Brain-derived 
      neurotrophic factor (BDNF) is a neurotrophic factor playing a critical role in 
      hippocampal synaptic plasticity and memory and whose levels have been shown 
      reduced in AD brains. While recent data support a pivotal role of beta-amyloid 
      peptides towards BDNF decrease, whether Tau pathology impacts on BDNF expression 
      remains unknown so far. In the present study, we have evaluated this relationship 
      using quantitative PCR, Western blot and ELISA in the THY-Tau22 transgenic 
      strain, known to display a progressive development of both hippocampal AD-like 
      Tau pathology and memory impairments. We observed that Tau pathology was not 
      associated with down-regulation of BDNF at the protein and mRNA levels in this 
      model, suggesting that the alteration of BDNF homeostasis observed in AD 
      patients' brains might rather be ascribed to amyloid pathology.
FAU - Burnouf, Sylvie
AU  - Burnouf S
AD  - Max-Planck Institute fur Biologie des Alterns/Max-Planck Institute for Biology of 
      Ageing, Koln, Germany. sylvie.burnouf@age.mpg.de
FAU - Belarbi, Karim
AU  - Belarbi K
FAU - Troquier, Laetitia
AU  - Troquier L
FAU - Derisbourg, Maxime
AU  - Derisbourg M
FAU - Demeyer, Dominique
AU  - Demeyer D
FAU - Leboucher, Antoine
AU  - Leboucher A
FAU - Laurent, Cyril
AU  - Laurent C
FAU - Hamdane, Malika
AU  - Hamdane M
FAU - Buee, Luc
AU  - Buee L
FAU - Blum, David
AU  - Blum D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Mutation/genetics
MH  - RNA, Messenger/metabolism
MH  - Tauopathies/genetics/*pathology
MH  - Up-Regulation/*genetics
MH  - tau Proteins/*genetics/metabolism
EDAT- 2012/01/26 06:00
MHDA- 2012/09/08 06:00
CRDT- 2012/01/26 06:00
PHST- 2011/07/14 00:00 [received]
PHST- 2011/10/10 00:00 [revised]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/09/08 06:00 [medline]
AID - CAR-EPUB-20120123-017 [pii]
AID - 10.2174/156720512800492468 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2012 May;9(4):406-10. doi: 10.2174/156720512800492468.