PMID- 22274732
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20120220
IS  - 1873-3913 (Electronic)
IS  - 0898-6568 (Linking)
VI  - 24
IP  - 5
DP  - 2012 May
TI  - Regulation of cell signaling and porcine reproductive and respiratory syndrome 
      virus.
PG  - 973-80
LID - 10.1016/j.cellsig.2012.01.004 [doi]
AB  - In order to successfully survive in host and persistent infection, porcine 
      reproductive and respiratory syndrome virus (PRRSV) utilized sophisticated 
      mechanisms to suppress or escape from the host' innate and adaptive immune 
      systems, and then changed host gene expression. Signaling pathways play a pivotal 
      role in the regulation of diverse biological processes. Once signaling pathways 
      are activated by a variety of different stimuli, immune responses will be 
      triggered by the activation of chemokines, transcription factors, and 
      inflammatory cytokines to adjust the aggressive replication and dissemination of 
      viruses. PRRSV infection is able to get many signaling pathways activation that 
      facilitates distinct cell functions to modulate immune responses. In addition, 
      the cross-talk of cell signaling pathways also can regulate PRRSV replication and 
      also is present in this review by recent finding.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Zhou, Ao
AU  - Zhou A
AD  - Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of 
      Education, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Zhang, Shujun
AU  - Zhang S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120117
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Gene Expression Regulation
MH  - *Host-Pathogen Interactions
MH  - *MAP Kinase Signaling System
MH  - Porcine Reproductive and Respiratory Syndrome/metabolism/pathology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Receptor Cross-Talk
MH  - Swine
MH  - Toll-Like Receptors/metabolism
EDAT- 2012/01/26 06:00
MHDA- 2012/06/07 06:00
CRDT- 2012/01/26 06:00
PHST- 2011/09/16 00:00 [received]
PHST- 2011/12/26 00:00 [revised]
PHST- 2012/01/10 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - S0898-6568(12)00009-5 [pii]
AID - 10.1016/j.cellsig.2012.01.004 [doi]
PST - ppublish
SO  - Cell Signal. 2012 May;24(5):973-80. doi: 10.1016/j.cellsig.2012.01.004. Epub 2012 
      Jan 17.