PMID- 22274880
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20130122
IS  - 1530-8022 (Electronic)
IS  - 0885-3282 (Linking)
VI  - 27
IP  - 6
DP  - 2013 Feb
TI  - Biocompatibility properties of surface-modified poly(dimethylsiloxane) for 
      urinary applications.
PG  - 651-60
LID - 10.1177/0885328211422119 [doi]
AB  - An electronic sensor system for urinary bladder pressure monitoring requires an 
      imbedding into a biocompatible, flexible, and liquid-impermeable material. 
      Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging 
      material because it fulfills the abovementioned requirements. However, the 
      surface of PDMS is hydrophobic and causes undesired interactions with salts, 
      proteins, and cells present in urine. To reduce possible interactions of urine 
      salts in the urinary bladder, monomers, 
      [2-(methacryloyloxy)ethyl]-dimethyl-3-sulfopropyl-ammonium hydroxide 
      (sulfobetaine) and 2-acrylamido-2-methylpropyl sulfonic acid, were grafted onto 
      the surface through oxygen plasma treatment. A reduction in salt deposition 
      between the pure PDMS and the modified PDMS was observed both in vitro 
      (artificial urine flow over the surface) and in vivo (implants into the urinary 
      bladder of experimental pigs). Additionally, a 10-fold reduction in salt 
      deposition was observed in vitro due to grafting of the monomers onto the 
      surface. These modified PDMS materials proved also to be biocompatible in cell 
      cultures, which was further confirmed by histological screening of the bladder 
      tissue after implantation in an in vivo pig model.
FAU - Lippens, Evi
AU  - Lippens E
AD  - Department of Basic Medical Sciences, Ghent University, Belgium.
FAU - De Smet, Nele
AU  - De Smet N
FAU - Schauvliege, Stijn
AU  - Schauvliege S
FAU - Martens, Ann
AU  - Martens A
FAU - Gasthuys, Frank
AU  - Gasthuys F
FAU - Schacht, Etienne
AU  - Schacht E
FAU - Cornelissen, Ria
AU  - Cornelissen R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120124
PL  - England
TA  - J Biomater Appl
JT  - Journal of biomaterials applications
JID - 8813912
RN  - 0 (Biocompatible Materials)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Salts)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Cells, Cultured
MH  - Chick Embryo
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Female
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Manometry/instrumentation
MH  - Materials Testing
MH  - *Prostheses and Implants
MH  - Salts/chemistry/urine
MH  - Surface Properties
MH  - Sus scrofa
MH  - Urinary Bladder/pathology/*physiology/*surgery
MH  - Urine/chemistry
EDAT- 2012/01/26 06:00
MHDA- 2013/09/06 06:00
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
AID - 0885328211422119 [pii]
AID - 10.1177/0885328211422119 [doi]
PST - ppublish
SO  - J Biomater Appl. 2013 Feb;27(6):651-60. doi: 10.1177/0885328211422119. Epub 2012 
      Jan 24.