PMID- 22274915
OWN - NLM
STAT- MEDLINE
DCOM- 20130726
LR  - 20220316
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Dec
TI  - High expression of CXCR2 is associated with tumorigenesis, progression, and 
      prognosis of laryngeal squamous cell carcinoma.
PG  - 2466-72
LID - 10.1007/s12032-011-0152-1 [doi]
AB  - The laryngeal squamous cell carcinoma (LSCC) is one of the most common cancers 
      threatening people's life. CXC-chemokine receptor type 2 (CXCR2) was reported to 
      play critical roles in angiogenesis, tumorigenesis, and metastasis of several 
      cancers such as colon cancer, melanoma, lung cancer, and so on. However, the 
      expression of CXCR2 in LSCC and its association with clinical characters of LSCC 
      remain unclear. Quantitative real-time reverse transcription-PCR and 
      immunohistochemistry were used, respectively, to analyze the mRNA level and 
      protein level of CXCR2 in 109 cases of LSCC tissues and 28 cases of 
      tumor-adjacent normal tissues. The expression of CXCR2 in LSCC was significantly 
      higher than that in tumor-adjacent tissues. Moreover, the expression level of 
      CXCR2 protein in LSCC was significantly related to lymph node metastasis 
      (P=.022), histopathological grade (P=.038), and 5 years' survival (P=.007). Cox 
      regression analysis revealed that CXCR2 expression (P=.031), as well as lymphatic 
      metastasis (P=.026) and TNM classification (P=.042), is an independent prognostic 
      marker of LSCC. High expression of CXCR2 is also associated with short survival 
      of LSCC patients. Our data indicate that the expression of CXCR2 is associated 
      with the development and progression of LSCC. CXCR2 expression may serve as an 
      independent prognostic marker for LSCC patients.
FAU - Han, Liang
AU  - Han L
AD  - Department of Head and Neck Surgery, Nantong Tuomor Hospital, Nantong, Jiangsu, 
      China.
FAU - Jiang, Bin
AU  - Jiang B
FAU - Wu, Hao
AU  - Wu H
FAU - Wang, Xudong
AU  - Wang X
FAU - Tang, Xiaojun
AU  - Tang X
FAU - Huang, Jianfei
AU  - Huang J
FAU - Zhu, Jin
AU  - Zhu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120125
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin-8B)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*etiology/mortality/pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*etiology/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Messenger/analysis
MH  - Receptors, Interleukin-8B/analysis/genetics/*physiology
EDAT- 2012/01/26 06:00
MHDA- 2013/07/28 06:00
CRDT- 2012/01/26 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2013/07/28 06:00 [medline]
AID - 10.1007/s12032-011-0152-1 [doi]
PST - ppublish
SO  - Med Oncol. 2012 Dec;29(4):2466-72. doi: 10.1007/s12032-011-0152-1. Epub 2012 Jan 
      25.