PMID- 22276228
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2151-321X (Print)
IS  - 2151-3228 (Electronic)
IS  - 2151-321X (Linking)
VI  - 24
IP  - 4
DP  - 2011 Dec
TI  - Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related 
      Phenotypes in a Puerto Rican Population.
PG  - 207-214
AB  - Recent studies have shown that osteopontin, a cytokine with suggested 
      immunoregulatory functions, may contribute to pathogenesis of asthma. To 
      determine whether single-nucleotide polymorphisms (SNPs) in SPP1, the gene 
      encoding osteopontin, are associated with risk of asthma, we genotyped 6 known 
      SNPs in SPP1 in the well-characterized Genetics of Asthma in Latino Americans 
      population of 294 Mexican and 365 Puerto Rican parent-child asthma trios. The 
      associations between SNPs and asthma or asthma-related phenotypes were examined 
      by transmission disequilibrium tests as implemented in the family-based 
      association test program. Three polymorphisms, 1 in exon 7 (rs1126616C) and 2 in 
      the 3'-untranslated region (rs1126772A and rs9138A) of SPP1, were associated with 
      diagnosis of asthma, severity of asthma, asthma in subjects with elevated 
      immunoglobulin E (IgE) (IgE >100 IU/mL), and postbronchodilator FEV(1) in Puerto 
      Ricans (P values=0.00007-0.04). The CC genotype of rs1126616 conferred an odds 
      ratio of 1.7 (95% CI=[1.3, 2.3], P value adjusted for multiple comparisons=0.001) 
      for asthma compared with the CT and TT genotypes. Furthermore, haplotype analysis 
      identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk 
      for asthma, severity of asthma, and asthma in subjects with elevated IgE 
      (P=0.03). There was no association between the SPP1 SNPs and asthma outcomes in 
      Mexicans. Our findings suggest that the SPP1 gene is a risk factor for asthma and 
      asthma-related phenotypes in Puerto Ricans, and are consistent with previous 
      animal and human studies on the role of osteopontin in pathogenesis of asthma.
FAU - Arjomandi, Mehrdad
AU  - Arjomandi M
FAU - Galanter, Josh M
AU  - Galanter JM
FAU - Choudhry, Shweta
AU  - Choudhry S
FAU - Eng, Celeste
AU  - Eng C
FAU - Hu, Donglei
AU  - Hu D
FAU - Beckman, Kenneth
AU  - Beckman K
FAU - Chapela, Rocio
AU  - Chapela R
FAU - Rodriguez-Santana, Jose R
AU  - Rodriguez-Santana JR
FAU - Rodriguez-Cintron, William
AU  - Rodriguez-Cintron W
FAU - Ford, Jean
AU  - Ford J
FAU - Avila, Pedro C
AU  - Avila PC
FAU - Burchard, Esteban G
AU  - Burchard EG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Allergy Immunol Pulmonol
JT  - Pediatric allergy, immunology, and pulmonology
JID - 101549629
PMC - PMC3255512
EDAT- 2012/01/26 06:00
MHDA- 2012/01/26 06:01
PMCR- 2011/12/01
CRDT- 2012/01/26 06:00
PHST- 2011/06/13 00:00 [received]
PHST- 2011/08/21 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/01/26 06:01 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - 10.1089/ped.2011.0095 [pii]
AID - 10.1089/ped.2011.0095 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol Pulmonol. 2011 Dec;24(4):207-214. doi: 
      10.1089/ped.2011.0095.