PMID- 22276260
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2230-9500 (Electronic)
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Linking)
VI  - 16
IP  - 1
DP  - 2012 Jan
TI  - Insulin sensitivity and beta-cell function in normoglycemic offspring of individuals 
      with type 2 diabetes mellitus: Impact of line of inheritance.
PG  - 105-11
LID - 10.4103/2230-8210.91204 [doi]
AB  - AIMS: The aim was to study the effect of family history of type 2 diabetes 
      mellitus (T2DM) on insulin sensitivity and beta-cell function in normoglycemic 
      offspring. MATERIAL AND METHODS: Offspring of T2DM patients (cases) and 
      individuals without family history of T2DM (controls) were the subjects for this 
      cross-sectional study. All participants underwent 75 g OGTT and samples were 
      collected for plasma insulin, C-peptide, and proinsulin at 0, 30, 60, and 120 
      minutes. RESULTS: A total of 271 cases (age 22 +/- 10 years; 53% males) and 259 
      controls (28 +/- 10 years, 66% males) were enrolled for the study. BMI, plasma 
      insulin, C-peptide, proinsulin, HOMA-IR, and insulinogenic index (0-120) were 
      significantly higher and whole-body insulin sensitivity (WBISI) and disposition 
      index (0-120) [DI 120] were lower in cases compared to controls. After adjusting 
      for BMI, proinsulin at 120 minutes, area under the curve (AUC) of proinsulin 
      (during OGTT) and AUC proinsulin/AUC C-peptide were significantly higher in 
      cases. Cases were subdivided into four groups according to inheritance pattern; 
      paternal DM (PDM), maternal DM (MDM), grandparental DM (GPDM), and both parents 
      DM (BPDM). The magnitude of differences varied with relationship (greater when 
      both parents and grandparents were affected). Mean HOMA-IR was higher by 127% and 
      50% and DI 120 was lower by 33% and 18% (adjusted for age and gender) in the BPDM 
      and GPDM groups respectively compared to controls. CONCLUSIONS: We observed 
      higher BMI, plasma insulin, C-peptide, and proinsulin and lower insulin 
      sensitivity and beta-cell compensation in normoglycemic offspring of T2DM subjects 
      compared to controls. Differences were greater when both parents and grandparents 
      had T2DM.
FAU - Praveen, Edavan P
AU  - Praveen EP
AD  - Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Sahoo, Jayaprakash
AU  - Sahoo J
FAU - Khurana, Madan L
AU  - Khurana ML
FAU - Kulshreshtha, Bindu
AU  - Kulshreshtha B
FAU - Khadgawat, Rajesh
AU  - Khadgawat R
FAU - Gupta, Nandita
AU  - Gupta N
FAU - Dwivedi, Sada Nand
AU  - Dwivedi SN
FAU - Kumar, Guresh
AU  - Kumar G
FAU - Prabhakaran, Dorairaj
AU  - Prabhakaran D
FAU - Ammini, Ariachery C
AU  - Ammini AC
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC3263177
OTO - NOTNLM
OT  - grandparental history of DM
OT  - insulin sensitivity
OT  - normoglycemic
OT  - offspring of individuals with type 2 diabetes
OT  - beta-cell function
COIS- Conflict of Interest: Nil.
EDAT- 2012/01/26 06:00
MHDA- 2012/01/26 06:01
PMCR- 2012/01/01
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/01/26 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - IJEM-16-105 [pii]
AID - 10.4103/2230-8210.91204 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2012 Jan;16(1):105-11. doi: 10.4103/2230-8210.91204.